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Research Article

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

  • Ricardo Rajsbaum,

    Affiliations: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Randy A. Albrecht,

    Affiliations: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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  • May K. Wang,

    Affiliation: Department of Microbiology and Immunobiology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

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  • Natalya P. Maharaj,

    Affiliation: Department of Microbiology and Immunobiology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

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  • Gijs A. Versteeg,

    Affiliations: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Estanislao Nistal-Villán,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America

    Current address: Center for Applied Medical Research (CIMA), Universidad de Navarra, Pamplona, Spain.

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  • Adolfo García-Sastre mail,

    adolfo.garcia-sastre@mssm.edu (AGS); michaela_gack@hms.harvard.edu (MUG)

    Affiliations: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America, Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Michaela U. Gack mail

    adolfo.garcia-sastre@mssm.edu (AGS); michaela_gack@hms.harvard.edu (MUG)

    Affiliation: Department of Microbiology and Immunobiology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

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  • Published: November 29, 2012
  • DOI: 10.1371/journal.ppat.1003059

About the Authors

Ricardo Rajsbaum, Randy A. Albrecht, Gijs A. Versteeg, Estanislao Nistal-Villán, Adolfo García-Sastre
Department of Microbiology, Mount Sinai School of Medicine, New York, New York, United States of America
Ricardo Rajsbaum, Randy A. Albrecht, Gijs A. Versteeg, Adolfo García-Sastre
Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York, United States of America
May K. Wang, Natalya P. Maharaj, Michaela U. Gack
Department of Microbiology and Immunobiology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
Adolfo García-Sastre
Department of Medicine, Mount Sinai School of Medicine, New York, New York, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RR MUG AGS. Performed the experiments: RR RAA MKW NPM MUG. Analyzed the data: RR MUG. Contributed reagents/materials/analysis tools: RAA GAV ENV. Wrote the paper: RR MUG AGS.