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Research Article

Block of Death-Receptor Apoptosis Protects Mouse Cytomegalovirus from Macrophages and Is a Determinant of Virulence in Immunodeficient Hosts

  • Linda Ebermann,

    Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Zsolt Ruzsics,

    Affiliation: Max von Pettenkofer Institute, Ludwig Maximilians University, Munich, Germany

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  • Carlos A. Guzmán,

    Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Nico van Rooijen,

    Affiliation: Department of Molecular Cell Biology, Faculty of Medicine, Vrije University, Amsterdam, The Netherlands

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  • Rosaely Casalegno-Garduño,

    Affiliation: Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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  • Ulrich Koszinowski,

    Affiliation: Max von Pettenkofer Institute, Ludwig Maximilians University, Munich, Germany

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  • Luka Čičin-Šain mail

    Luka.Cicin-Sain@helmholtz-hzi.de

    Affiliations: Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany, Department of Virology, Hannover School of Medicine, Hannover, Germany

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  • Published: December 13, 2012
  • DOI: 10.1371/journal.ppat.1003062

About the Authors

Linda Ebermann, Carlos A. Guzmán, Rosaely Casalegno-Garduño, Luka Čičin-Šain
Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
Zsolt Ruzsics, Ulrich Koszinowski
Max von Pettenkofer Institute, Ludwig Maximilians University, Munich, Germany
Nico van Rooijen
Department of Molecular Cell Biology, Faculty of Medicine, Vrije University, Amsterdam, The Netherlands
Luka Čičin-Šain
Department of Virology, Hannover School of Medicine, Hannover, Germany

Corresponding Author

Email: Luka.Cicin-Sain@helmholtz-hzi.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LE ZR LCS. Performed the experiments: LE LCS RCG. Analyzed the data: LE ZR UK LCS RCG. Contributed reagents/materials/analysis tools: CAG NvR. Wrote the paper: LE LCS.