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Research Article

Influenza Human Monoclonal Antibody 1F1 Interacts with Three Major Antigenic Sites and Residues Mediating Human Receptor Specificity in H1N1 Viruses

  • Tshidi Tsibane equal contributor,

    equal contributor Contributed equally to this work with: Tshidi Tsibane, Damian C. Ekiert, Jens C. Krause

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America

    X
  • Damian C. Ekiert equal contributor,

    equal contributor Contributed equally to this work with: Tshidi Tsibane, Damian C. Ekiert, Jens C. Krause

    Affiliation: Department of Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

    X
  • Jens C. Krause equal contributor,

    equal contributor Contributed equally to this work with: Tshidi Tsibane, Damian C. Ekiert, Jens C. Krause

    Affiliation: Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    X
  • Osvaldo Martinez,

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America

    X
  • James E. Crowe Jr. mail,

    james.crowe@vanderbilt.edu (JEC); wilson@scripps.edu (IAW); chris.basler@mssm.edu (CFB)

    Affiliations: Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    X
  • Ian A. Wilson mail,

    james.crowe@vanderbilt.edu (JEC); wilson@scripps.edu (IAW); chris.basler@mssm.edu (CFB)

    Affiliation: Department of Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

    X
  • Christopher F. Basler mail

    james.crowe@vanderbilt.edu (JEC); wilson@scripps.edu (IAW); chris.basler@mssm.edu (CFB)

    Affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America

    X
  • Published: December 06, 2012
  • DOI: 10.1371/journal.ppat.1003067

About the Authors

Tshidi Tsibane, Osvaldo Martinez, Christopher F. Basler
Department of Microbiology, Mount Sinai School of Medicine, New York City, New York, United States of America
Damian C. Ekiert, Ian A. Wilson
Department of Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America
Jens C. Krause, James E. Crowe Jr.
Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
James E. Crowe Jr.
Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TT DCE JCK OM JEC IAW CFB. Performed the experiments: TT DCE JCK OM. Analyzed the data: TT DCE JCK OM JEC IAW CFB. Wrote the paper: TT DCE JCK JEC IAW CFB.