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Research Article

Hsp90 Orchestrates Transcriptional Regulation by Hsf1 and Cell Wall Remodelling by MAPK Signalling during Thermal Adaptation in a Pathogenic Yeast

  • Michelle D. Leach mail,

    michelle.leach@abdn.ac.uk

    Affiliations: Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom, Department of Molecular Genetics, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

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  • Susan Budge,

    Affiliation: Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom

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  • Louise Walker,

    Affiliation: Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom

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  • Carol Munro,

    Affiliation: Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom

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  • Leah E. Cowen,

    Affiliation: Department of Molecular Genetics, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

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  • Alistair J. P. Brown

    Affiliation: Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom

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  • Published: December 27, 2012
  • DOI: 10.1371/journal.ppat.1003069

About the Authors

Michelle D. Leach, Susan Budge, Louise Walker, Carol Munro, Alistair J. P. Brown
Aberdeen Fungal Group, School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom
Michelle D. Leach, Leah E. Cowen
Department of Molecular Genetics, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada

Corresponding Author

Email: michelle.leach@abdn.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MDL AJPB. Performed the experiments: MDL SB LW. Analyzed the data: MDL CM LEC AJPB. Wrote the paper: MDL LEC AJPB.