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Research Article

MiniCD4 Microbicide Prevents HIV Infection of Human Mucosal Explants and Vaginal Transmission of SHIV162P3 in Cynomolgus Macaques

  • Nathalie Dereuddre-Bosquet,

    Affiliations: CEA, Division of Immuno-Virology, iMETI, Fontenay-aux Roses, France, Paris-Sud University, UMRE01, Orsay, France

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  • Laurence Morellato-Castillo,

    Affiliation: CEA, iBiTecS, Service d'Ingénierie Moléculaire des Protéines, Gif sur Yvette, France

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  • Joachim Brouwers,

    Affiliation: Katholieke Universiteit Leuven, Leuven, Belgium

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  • Patrick Augustijns,

    Affiliation: Katholieke Universiteit Leuven, Leuven, Belgium

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  • Kawthar Bouchemal,

    Affiliation: Paris-Sud University, Faculty of Pharmacy, Chatenay-Malabry, France

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  • Gilles Ponchel,

    Affiliation: Paris-Sud University, Faculty of Pharmacy, Chatenay-Malabry, France

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  • Oscar H. P. Ramos,

    Affiliation: CEA, iBiTecS, Service d'Ingénierie Moléculaire des Protéines, Gif sur Yvette, France

    X
  • Carolina Herrera,

    Affiliation: Section of Infectious Diseases, Faculty of Medicine, St Mary's Campus, Imperial College, London, United Kingdom

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  • Martha Stefanidou,

    Affiliation: Department of Pediatrics and Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Robin Shattock,

    Affiliation: Section of Infectious Diseases, Faculty of Medicine, St Mary's Campus, Imperial College, London, United Kingdom

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  • Leo Heyndrickx,

    Affiliation: Institute of Tropical Medicine and University of Antwerp, Antwerp, Belgium

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  • Guido Vanham,

    Affiliation: Institute of Tropical Medicine and University of Antwerp, Antwerp, Belgium

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  • Pascal Kessler,

    Affiliation: CEA, iBiTecS, Service d'Ingénierie Moléculaire des Protéines, Gif sur Yvette, France

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  • Roger Le Grand,

    Affiliations: CEA, Division of Immuno-Virology, iMETI, Fontenay-aux Roses, France, Paris-Sud University, UMRE01, Orsay, France

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  • Loïc Martin mail

    loic.martin@cea.fr

    Affiliation: CEA, iBiTecS, Service d'Ingénierie Moléculaire des Protéines, Gif sur Yvette, France

    X
  • Published: December 06, 2012
  • DOI: 10.1371/journal.ppat.1003071

About the Authors

Nathalie Dereuddre-Bosquet, Roger Le Grand
CEA, Division of Immuno-Virology, iMETI, Fontenay-aux Roses, France
Nathalie Dereuddre-Bosquet, Roger Le Grand
Paris-Sud University, UMRE01, Orsay, France
Laurence Morellato-Castillo, Oscar H. P. Ramos, Pascal Kessler, Loïc Martin
CEA, iBiTecS, Service d'Ingénierie Moléculaire des Protéines, Gif sur Yvette, France
Joachim Brouwers, Patrick Augustijns
Katholieke Universiteit Leuven, Leuven, Belgium
Kawthar Bouchemal, Gilles Ponchel
Paris-Sud University, Faculty of Pharmacy, Chatenay-Malabry, France
Carolina Herrera, Robin Shattock
Section of Infectious Diseases, Faculty of Medicine, St Mary's Campus, Imperial College, London, United Kingdom
Martha Stefanidou
Department of Pediatrics and Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
Leo Heyndrickx, Guido Vanham
Institute of Tropical Medicine and University of Antwerp, Antwerp, Belgium

Corresponding Author

Email: loic.martin@cea.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NDB PA GP RS GV PK RL LM. Performed the experiments: NDB JB KB CH MS LH. Analyzed the data: NDB OHPR CH RL LM. Contributed reagents/materials/analysis tools: NDB LMC JB KB CH PK. Wrote the paper: NDB CH RS GV PK RL LM.