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Research Article

Clostridium difficile Toxin B Causes Epithelial Cell Necrosis through an Autoprocessing-Independent Mechanism

  • Nicole M. Chumbler,

    Affiliation: Chemical and Physical Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Melissa A. Farrow,

    Affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Lynne A. Lapierre,

    Affiliation: Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Jeffrey L. Franklin,

    Affiliations: Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cell and Developmental Biology and the Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • David Haslam,

    Affiliation: Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • James R. Goldenring,

    Affiliations: Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cell and Developmental Biology and the Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • D. Borden Lacy mail

    borden.lacy@vanderbilt.edu

    Affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Published: December 06, 2012
  • DOI: 10.1371/journal.ppat.1003072

About the Authors

Nicole M. Chumbler
Chemical and Physical Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Melissa A. Farrow, D. Borden Lacy
Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Lynne A. Lapierre, James R. Goldenring
Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Jeffrey L. Franklin
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Jeffrey L. Franklin, James R. Goldenring
Department of Cell and Developmental Biology and the Epithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
David Haslam
Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States of America

Corresponding Author

Email: borden.lacy@vanderbilt.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NMC MAF LAL JRG DBL. Performed the experiments: NMC LAL. Analyzed the data: NMC MAF LAL JLF JRG DBL. Contributed reagents/materials/analysis tools: DH. Wrote the paper: NMC DBL.