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Research Article

The Polyfunctionality of Human Memory CD8+ T Cells Elicited by Acute and Chronic Virus Infections Is Not Influenced by Age

  • Alina Lelic,

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Chris P. Verschoor,

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Mario Ventresca,

    Affiliation: Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada

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  • Robin Parsons,

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Carole Evelegh,

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Dawn Bowdish,

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Michael R. Betts,

    Affiliation: Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States

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  • Mark B. Loeb,

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Jonathan L. Bramson mail

    bramsonj@mcmaster.ca

    Affiliation: McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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  • Published: December 13, 2012
  • DOI: 10.1371/journal.ppat.1003076

About the Authors

Alina Lelic, Chris P. Verschoor, Robin Parsons, Carole Evelegh, Dawn Bowdish, Mark B. Loeb, Jonathan L. Bramson
McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Mario Ventresca
Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, Canada
Michael R. Betts
Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Corresponding Author

Email: bramsonj@mcmaster.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AL JLB. Performed the experiments: AL RP CE. Analyzed the data: AL CPV MV. Contributed reagents/materials/analysis tools: MRB MBL. Wrote the paper: AL CPV MV DB JLB MRB.