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Research Article

Global Gene Transcriptome Analysis in Vaccinated Cattle Revealed a Dominant Role of IL-22 for Protection against Bovine Tuberculosis

  • Sabin Bhuju equal contributor,

    equal contributor Contributed equally to this work with: Sabin Bhuju, Elihu Aranday-Cortes

    Affiliations: Helmholtz Centre for Infection Research, Braunschweig, Germany, Lionex Diagnostics Ltd, Braunschweig, Germany

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  • Elihu Aranday-Cortes equal contributor,

    equal contributor Contributed equally to this work with: Sabin Bhuju, Elihu Aranday-Cortes

    Affiliation: Department of Bovine Tuberculosis, Animal Health and Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, United Kingdom

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  • Bernardo Villarreal-Ramos,

    Affiliation: Department of Bovine Tuberculosis, Animal Health and Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, United Kingdom

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  • Zhou Xing,

    Affiliation: McMaster University, Hamilton, Ontario, Canada

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  • Mahavir Singh,

    Affiliations: Helmholtz Centre for Infection Research, Braunschweig, Germany, Lionex Diagnostics Ltd, Braunschweig, Germany

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  • H. Martin Vordermeier mail

    martin.vordermeier@ahvla.gsi.gov.uk

    Affiliation: Department of Bovine Tuberculosis, Animal Health and Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, United Kingdom

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  • Published: December 27, 2012
  • DOI: 10.1371/journal.ppat.1003077

About the Authors

Sabin Bhuju, Mahavir Singh
Helmholtz Centre for Infection Research, Braunschweig, Germany
Sabin Bhuju, Mahavir Singh
Lionex Diagnostics Ltd, Braunschweig, Germany
Elihu Aranday-Cortes, Bernardo Villarreal-Ramos, H. Martin Vordermeier
Department of Bovine Tuberculosis, Animal Health and Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey, United Kingdom
Zhou Xing
McMaster University, Hamilton, Ontario, Canada

Corresponding Author

Email: martin.vordermeier@ahvla.gsi.gov.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BVR MS HMV ZX. Performed the experiments: SB EAC BVR. Analyzed the data: SB EAC BVR HMV. Contributed reagents/materials/analysis tools: ZX. Wrote the paper: SB EAC BVR HMV.