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Research Article

The GM2 Glycan Serves as a Functional Coreceptor for Serotype 1 Reovirus

  • Kerstin Reiss equal contributor,

    equal contributor Contributed equally to this work with: Kerstin Reiss, Jennifer E. Stencel

    Affiliation: Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany

    X
  • Jennifer E. Stencel equal contributor,

    equal contributor Contributed equally to this work with: Kerstin Reiss, Jennifer E. Stencel

    Affiliations: Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Yan Liu,

    Affiliation: Glycosciences Laboratory, Department of Medicine, Imperial College London, London, United Kingdom

    X
  • Bärbel S. Blaum,

    Affiliation: Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany

    X
  • Dirk M. Reiter,

    Affiliation: Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany

    X
  • Ten Feizi,

    Affiliation: Glycosciences Laboratory, Department of Medicine, Imperial College London, London, United Kingdom

    X
  • Terence S. Dermody mail,

    terry.dermody@vanderbilt.edu (TSD); thilo.stehle@uni-tuebingen.de (TS)

    Affiliations: Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Thilo Stehle mail

    terry.dermody@vanderbilt.edu (TSD); thilo.stehle@uni-tuebingen.de (TS)

    Affiliations: Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Published: December 06, 2012
  • DOI: 10.1371/journal.ppat.1003078

About the Authors

Kerstin Reiss, Bärbel S. Blaum, Dirk M. Reiter, Thilo Stehle
Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany
Jennifer E. Stencel, Terence S. Dermody
Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Jennifer E. Stencel, Terence S. Dermody
Elizabeth B. Lamb Center for Pediatric Research, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Yan Liu, Ten Feizi
Glycosciences Laboratory, Department of Medicine, Imperial College London, London, United Kingdom
Terence S. Dermody, Thilo Stehle
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KR JES YL TSD TS. Performed the experiments: KR JES YL BSB. Analyzed the data: KR JES YL BSB DMR TF TSD TS. Wrote the paper: KR JES YL BSB TF TSD TS.