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Research Article

VipD of Legionella pneumophila Targets Activated Rab5 and Rab22 to Interfere with Endosomal Trafficking in Macrophages

  • Bonsu Ku equal contributor,

    equal contributor Contributed equally to this work with: Bonsu Ku, Kwang-Hoon Lee

    Affiliation: Department of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea

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  • Kwang-Hoon Lee equal contributor,

    equal contributor Contributed equally to this work with: Bonsu Ku, Kwang-Hoon Lee

    Affiliation: Department of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea

    Current address: Bio Research Center, Samsung Advanced Institute of Technology, Yongin, Korea

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  • Wei Sun Park,

    Affiliation: Department of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea

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  • Chul-Su Yang,

    Affiliation: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

    Current address: Department of Microbiology and Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Korea

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  • Jianning Ge,

    Affiliations: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, National Institute of Biological Sciences, Beijing, China

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  • Seong-Gyu Lee,

    Affiliation: Department of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea

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  • Sun-Shin Cha,

    Affiliation: Marine Biotechnology Research Center, Korea Ocean Research and Development Institute, Ansan, Korea

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  • Feng Shao,

    Affiliation: National Institute of Biological Sciences, Beijing, China

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  • Won Do Heo,

    Affiliation: Department of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea

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  • Jae U. Jung,

    Affiliation: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Byung-Ha Oh mail

    bhoh@kaist.ac.kr

    Affiliation: Department of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea

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  • Published: December 13, 2012
  • DOI: 10.1371/journal.ppat.1003082

About the Authors

Bonsu Ku, Kwang-Hoon Lee, Wei Sun Park, Seong-Gyu Lee, Won Do Heo, Byung-Ha Oh
Department of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon, Korea
Chul-Su Yang, Jianning Ge, Jae U. Jung
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Jianning Ge, Feng Shao
National Institute of Biological Sciences, Beijing, China
Sun-Shin Cha
Marine Biotechnology Research Center, Korea Ocean Research and Development Institute, Ansan, Korea

Corresponding Author

Email: bhoh@kaist.ac.kr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BK KHL JUJ BHO. Performed the experiments: BK KHL WSP CSY JG SGL. Analyzed the data: BK KHL WDH JUJ BHO. Contributed reagents/materials/analysis tools: SSC FS. Wrote the paper: BK KHL BHO.