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Research Article

Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G

  • David J. Stanley equal contributor,

    equal contributor Contributed equally to this work with: David J. Stanley, Koen Bartholomeeusen

    Affiliations: Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America, Graduate Program in Biophysics, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Koen Bartholomeeusen equal contributor,

    equal contributor Contributed equally to this work with: David J. Stanley, Koen Bartholomeeusen

    Affiliation: Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America

    X
  • David C. Crosby,

    Affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Dong Young Kim,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Eunju Kwon,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Linda Yen,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Nathalie Caretta Cartozo,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Ming Li,

    Affiliation: Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

    X
  • Stefanie Jäger,

    Affiliation: Department of Molecular and Cellular Pharmacology, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Jeremy Mason-Herr,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Fumiaki Hayashi,

    Affiliation: RIKEN Systems and Structural Biology Center, Tsurumi, Yokohama, Japan

    X
  • Shigeyuki Yokoyama,

    Affiliations: RIKEN Systems and Structural Biology Center, Tsurumi, Yokohama, Japan, Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan

    X
  • Nevan J. Krogan,

    Affiliations: Department of Molecular and Cellular Pharmacology, University of California, San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, QB3, University of California, San Francisco, San Francisco, California, United States of America, J. David Gladstone Institutes, San Francisco, California, United States of America

    X
  • Reuben S. Harris,

    Affiliation: Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

    X
  • Boris Matija Peterlin,

    Affiliation: Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America

    X
  • John D. Gross mail

    jdgross@cgl.ucsf.edu

    Affiliations: Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, QB3, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Published: December 27, 2012
  • DOI: 10.1371/journal.ppat.1003085

About the Authors

David J. Stanley, Dong Young Kim, Eunju Kwon, Linda Yen, Nathalie Caretta Cartozo, Jeremy Mason-Herr, John D. Gross
Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America
David J. Stanley
Graduate Program in Biophysics, University of California, San Francisco, San Francisco, California, United States of America
Koen Bartholomeeusen, Boris Matija Peterlin
Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America
David C. Crosby
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America
Ming Li, Reuben S. Harris
Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America
Stefanie Jäger, Nevan J. Krogan
Department of Molecular and Cellular Pharmacology, University of California, San Francisco, San Francisco, California, United States of America
Fumiaki Hayashi, Shigeyuki Yokoyama
RIKEN Systems and Structural Biology Center, Tsurumi, Yokohama, Japan
Shigeyuki Yokoyama
Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan
Nevan J. Krogan, John D. Gross
California Institute for Quantitative Biosciences, QB3, University of California, San Francisco, San Francisco, California, United States of America
Nevan J. Krogan
J. David Gladstone Institutes, San Francisco, California, United States of America

Corresponding Author

Email: jdgross@cgl.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DJS KB DCC NJK RSH BMP JDG. Performed the experiments: DJS KB DCC LY EK ML NCC SJ FH. Analyzed the data: DJS KB DCC NCC BMP JDG. Contributed reagents/materials/analysis tools: ML DYK SJ JMH FH SY RSH NJK. Wrote the paper: DJS KB BMP JDG.