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Research Article

Nasal Colonisation by Staphylococcus aureus Depends upon Clumping Factor B Binding to the Squamous Epithelial Cell Envelope Protein Loricrin

  • Michelle E. Mulcahy,

    Affiliation: Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, Ireland

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  • Joan A. Geoghegan,

    Affiliation: Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, Ireland

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  • Ian R. Monk,

    Affiliation: Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, Ireland

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  • Kate M. O'Keeffe,

    Affiliation: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

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  • Evelyn J. Walsh,

    Affiliation: Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, Ireland

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  • Timothy J. Foster equal contributor,

    equal contributor Contributed equally to this work with: Timothy J. Foster, Rachel M. McLoughlin

    Affiliation: Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, Ireland

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  • Rachel M. McLoughlin equal contributor mail

    equal contributor Contributed equally to this work with: Timothy J. Foster, Rachel M. McLoughlin

    rachel.mcloughlin@tcd.ie

    Affiliation: School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

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  • Published: December 27, 2012
  • DOI: 10.1371/journal.ppat.1003092

About the Authors

Michelle E. Mulcahy, Joan A. Geoghegan, Ian R. Monk, Evelyn J. Walsh, Timothy J. Foster
Department of Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, Ireland
Kate M. O'Keeffe, Rachel M. McLoughlin
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

Corresponding Author

Email: rachel.mcloughlin@tcd.ie

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MEM JAG EJW TJF RMM. Performed the experiments: MEM JAG IRM KMOK. Analyzed the data: MEM JAG RMM KMOK. Wrote the paper: MEM JAG TJF RMM.