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Research Article

Central Nervous System Compartmentalization of HIV-1 Subtype C Variants Early and Late in Infection in Young Children

  • Christa Buckheit Sturdevant,

    Affiliation: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Anna Dow,

    Affiliation: Department of Epidemiology, University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America

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  • Cassandra B. Jabara,

    Affiliations: Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Sarah B. Joseph,

    Affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Gretja Schnell,

    Affiliation: Department of Immunology, University of Washington, Seattle, Washington, United States of America

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  • Nobutoki Takamune,

    Affiliation: Department of Pharmaceutical Biochemistry, Kumamoto University, Kumamoto, Japan

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  • Macpherson Mallewa,

    Affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Program, University of Malawi College of Medicine, Blantyre, Malawi

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  • Robert S. Heyderman,

    Affiliation: Malawi-Liverpool-Wellcome Trust Clinical Research Program, University of Malawi College of Medicine, Blantyre, Malawi

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  • Annelies Van Rie,

    Affiliation: Department of Epidemiology, University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America

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  • Ronald Swanstrom mail

    risunc@med.unc.edu

    Affiliations: Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Published: December 27, 2012
  • DOI: 10.1371/journal.ppat.1003094

About the Authors

Christa Buckheit Sturdevant, Ronald Swanstrom
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Anna Dow, Annelies Van Rie
Department of Epidemiology, University of North Carolina at Chapel Hill, Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America
Cassandra B. Jabara
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Cassandra B. Jabara, Ronald Swanstrom
UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Cassandra B. Jabara, Sarah B. Joseph, Ronald Swanstrom
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Gretja Schnell
Department of Immunology, University of Washington, Seattle, Washington, United States of America
Nobutoki Takamune
Department of Pharmaceutical Biochemistry, Kumamoto University, Kumamoto, Japan
Macpherson Mallewa, Robert S. Heyderman
Malawi-Liverpool-Wellcome Trust Clinical Research Program, University of Malawi College of Medicine, Blantyre, Malawi
Ronald Swanstrom
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: risunc@med.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CBS AD CBJ SBJ GS MM RSH AVR RS. Performed the experiments: CBS AD CBJ SBJ GS NT MM RSH. Analyzed the data: CBS AD CBJ SBJ GS NT MM RSH AVR RS. Wrote the paper: CBS AD CBJ SBJ GS NT MM RSH AVR RS.