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Research Article

4′-Phosphopantetheinyl Transferase PptT, a New Drug Target Required for Mycobacterium tuberculosis Growth and Persistence In Vivo

  • Cécile Leblanc,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Thomas Prudhomme,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

    Current address: Biosentec, Toulouse, France.

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  • Guillaume Tabouret,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

    Current address: INRA UMR 1225, IHAP, Ecole Nationale Vétérinaire, Toulouse, France.

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  • Aurélie Ray,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

    Current address: Trudeau Institute, Saranac Lake, New York, United States of America.

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  • Sophie Burbaud,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Stéphanie Cabantous,

    Affiliation: Centre de Recherche en Cancérologie (CRCT), UMR 1037 INSERM-CNRS-UPS Institut Claudius Regaud, Toulouse, France

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  • Lionel Mourey,

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Christophe Guilhot mail,

    Christian.Chalut@ipbs.fr (CC); Christophe.Guilhot@ipbs.fr (CG)

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Christian Chalut mail

    Christian.Chalut@ipbs.fr (CC); Christophe.Guilhot@ipbs.fr (CG)

    Affiliations: CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France, Université de Toulouse, UPS, IPBS, Toulouse, France

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  • Published: December 20, 2012
  • DOI: 10.1371/journal.ppat.1003097

About the Authors

Cécile Leblanc, Thomas Prudhomme, Guillaume Tabouret, Aurélie Ray, Sophie Burbaud, Lionel Mourey, Christophe Guilhot, Christian Chalut
CNRS, IPBS (Institut de Pharmacologie et de Biologie Structurale), Toulouse, France
Cécile Leblanc, Thomas Prudhomme, Guillaume Tabouret, Aurélie Ray, Sophie Burbaud, Lionel Mourey, Christophe Guilhot, Christian Chalut
Université de Toulouse, UPS, IPBS, Toulouse, France
Stéphanie Cabantous
Centre de Recherche en Cancérologie (CRCT), UMR 1037 INSERM-CNRS-UPS Institut Claudius Regaud, Toulouse, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CL TP GT CC. Performed the experiments: CL TP GT AR SB. Analyzed the data: CL CG CC. Contributed reagents/materials/analysis tools: CL TP SC LM. Wrote the paper: CC CG.