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Research Article

Messenger RNA Sequence Rather than Protein Sequence Determines the Level of Self-synthesis and Antigen Presentation of the EBV-encoded Antigen, EBNA1

  • Judy T. Tellam mail,

    Judy.Tellam@qimr.edu.au

    Affiliation: Tumour Immunology, Department of Immunology, Clive Berghofer Cancer Research Centre and Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Herston, Queensland, Australia

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  • Lea Lekieffre,

    Affiliation: Tumour Immunology, Department of Immunology, Clive Berghofer Cancer Research Centre and Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Herston, Queensland, Australia

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  • Jie Zhong,

    Affiliation: Tumour Immunology, Department of Immunology, Clive Berghofer Cancer Research Centre and Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Herston, Queensland, Australia

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  • David J. Lynn,

    Affiliation: Animal and Bioscience Research Department, AGRIC, Teagasc, Grange, Dunsany, Co. Meath, Ireland

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  • Rajiv Khanna

    Affiliation: Tumour Immunology, Department of Immunology, Clive Berghofer Cancer Research Centre and Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Herston, Queensland, Australia

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  • Published: December 27, 2012
  • DOI: 10.1371/journal.ppat.1003112

About the Authors

Judy T. Tellam, Lea Lekieffre, Jie Zhong, Rajiv Khanna
Tumour Immunology, Department of Immunology, Clive Berghofer Cancer Research Centre and Australian Centre for Vaccine Development, Queensland Institute of Medical Research, Herston, Queensland, Australia
David J. Lynn
Animal and Bioscience Research Department, AGRIC, Teagasc, Grange, Dunsany, Co. Meath, Ireland

Corresponding Author

Email: Judy.Tellam@qimr.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JTT LL. Performed the experiments: JTT LL JZ. Analyzed the data: JTT LL JZ DJL RK. Contributed reagents/materials/analysis tools: JTT LL DJL RK. Wrote the paper: JTT.