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Research Article

Granzyme A Produced by γ9δ2 T Cells Induces Human Macrophages to Inhibit Growth of an Intracellular Pathogen

  • Charles T. Spencer equal contributor,

    equal contributor Contributed equally to this work with: Charles T. Spencer, Getahun Abate, Isaac G. Sakala

    Affiliations: Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, United States of America, Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America

    Current address: Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, United States of America.

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  • Getahun Abate equal contributor,

    equal contributor Contributed equally to this work with: Charles T. Spencer, Getahun Abate, Isaac G. Sakala

    Affiliation: Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, United States of America

    X
  • Isaac G. Sakala equal contributor,

    equal contributor Contributed equally to this work with: Charles T. Spencer, Getahun Abate, Isaac G. Sakala

    Affiliation: Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, United States of America

    Current address: Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, Missouri, United States of America.

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  • Mei Xia,

    Affiliation: Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, United States of America

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  • Steven M. Truscott,

    Affiliation: Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, United States of America

    Current address: Department of Pathology and Laboratory Medicine, Beaumont Health System, Royal Oak, Missouri, United States of America.

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  • Christopher S. Eickhoff,

    Affiliation: Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, United States of America

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  • Rebecca Linn,

    Affiliation: Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, United States of America

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  • Azra Blazevic,

    Affiliation: Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, United States of America

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  • Sunil S. Metkar,

    Affiliation: NorthShore University HealthSystems Research Institute, Evanston, Illinois, United States of America

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  • Guangyong Peng,

    Affiliation: Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, United States of America

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  • Christopher J. Froelich,

    Affiliation: NorthShore University HealthSystems Research Institute, Evanston, Illinois, United States of America

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  • Daniel F. Hoft mail

    hoftdf@slu.edu

    Affiliations: Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, United States of America, Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America

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  • Published: January 10, 2013
  • DOI: 10.1371/journal.ppat.1003119

About the Authors

Charles T. Spencer, Getahun Abate, Isaac G. Sakala, Mei Xia, Steven M. Truscott, Christopher S. Eickhoff, Rebecca Linn, Azra Blazevic, Guangyong Peng, Daniel F. Hoft
Division of Infectious Diseases, Allergy and Immunology, Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, United States of America
Charles T. Spencer, Daniel F. Hoft
Department of Molecular Microbiology and Immunology, Saint Louis University, St. Louis, Missouri, United States of America
Sunil S. Metkar, Christopher J. Froelich
NorthShore University HealthSystems Research Institute, Evanston, Illinois, United States of America

Corresponding Author

Email: hoftdf@slu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CTS GA IGS MX SMT CSE RL AB SSM GP CJF DFH. Performed the experiments: CTS GA IGS MX SMT CSE RL AB SSM. Analyzed the data: CTS GA IGS MX SMT CSE RL AB SSM GP CJF DFH. Contributed reagents/materials/analysis tools: CTS GA IGS MX SMT CSE RL AB SSM GP CJF DFH. Wrote the paper: CTS GA IGS MX SMT CSE RL AB SSM GP CJF DFH.