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Research Article

A Pathogen Type III Effector with a Novel E3 Ubiquitin Ligase Architecture

  • Alexander U. Singer equal contributor,

    equal contributor Contributed equally to this work with: Alexander U. Singer, Sebastian Schulze

    Affiliations: Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada, Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

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  • Sebastian Schulze equal contributor,

    equal contributor Contributed equally to this work with: Alexander U. Singer, Sebastian Schulze

    Affiliation: Department of Genetics, Martin Luther University Halle-Wittenberg, Halle, Germany

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  • Tatiana Skarina,

    Affiliations: Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada, Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

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  • Xiaohui Xu,

    Affiliations: Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada, Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

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  • Hong Cui,

    Affiliations: Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada, Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

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  • Lennart Eschen-Lippold,

    Affiliation: Leibniz Institute of Plant Biochemistry, Halle, Germany

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  • Monique Egler,

    Affiliation: Department of Genetics, Martin Luther University Halle-Wittenberg, Halle, Germany

    Current address: Scil Proteins GmbH, Halle, Germany.

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  • Tharan Srikumar,

    Affiliation: Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, MaRS TMDT 9-805, Toronto, Ontario, Canada

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  • Brian Raught,

    Affiliation: Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, MaRS TMDT 9-805, Toronto, Ontario, Canada

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  • Justin Lee,

    Affiliation: Leibniz Institute of Plant Biochemistry, Halle, Germany

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  • Dierk Scheel,

    Affiliation: Leibniz Institute of Plant Biochemistry, Halle, Germany

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  • Alexei Savchenko mail,

    alexei.savchenko@utoronto.ca (AS); ulla.bonas@genetik.uni-halle.de (UB)

    Affiliations: Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada, Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada

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  • Ulla Bonas mail

    alexei.savchenko@utoronto.ca (AS); ulla.bonas@genetik.uni-halle.de (UB)

    Affiliation: Department of Genetics, Martin Luther University Halle-Wittenberg, Halle, Germany

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  • Published: January 24, 2013
  • DOI: 10.1371/journal.ppat.1003121

About the Authors

Alexander U. Singer, Tatiana Skarina, Xiaohui Xu, Hong Cui, Alexei Savchenko
Banting and Best Department for Medical Research, University of Toronto, C.H. Best Institute, Toronto, Ontario, Canada
Alexander U. Singer, Tatiana Skarina, Xiaohui Xu, Hong Cui, Alexei Savchenko
Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada
Sebastian Schulze, Monique Egler, Ulla Bonas
Department of Genetics, Martin Luther University Halle-Wittenberg, Halle, Germany
Lennart Eschen-Lippold, Justin Lee, Dierk Scheel
Leibniz Institute of Plant Biochemistry, Halle, Germany
Tharan Srikumar, Brian Raught
Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, MaRS TMDT 9-805, Toronto, Ontario, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: A.U. Singer, S. Schulze, X. Xu, T. Srikumar, B. Raught, U. Bonas, A. Savchenko, L. Eschen-Lippold, J. Lee, D. Scheel. Performed the experiments: A.U. Singer, S. Schulze. X. Xu, T. Srikumar, H. Cui, M. Egler, T. Skarina, L. Eschen-Lippold. Analyzed the data: A.U. Singer, S. Schulze, T. Skarina, T. Srikumar, M. Egler, B. Raught, U. Bonas, A. Savchenko, L. Eschen-Lippold, J. Lee, D. Scheel. Contributed reagents/materials/analysis tools: X. Xu, H. Cui, B. Raught, J. Lee, D. Scheel. Wrote the paper: A.U. Singer, S. Schulze, U. Bonas, A. Savchenko.