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Research Article

The Hepatitis B Virus Ribonuclease H Is Sensitive to Inhibitors of the Human Immunodeficiency Virus Ribonuclease H and Integrase Enzymes

  • John E. Tavis mail,

    tavisje@slu.edu

    Affiliations: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America, Saint Louis University Liver Center, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • Xiaohong Cheng equal contributor,

    equal contributor Contributed equally to this work with: Xiaohong Cheng, Yuan Hu

    Affiliation: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • Yuan Hu equal contributor,

    equal contributor Contributed equally to this work with: Xiaohong Cheng, Yuan Hu

    Affiliations: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America, Key Laboratory of Molecular Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China

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  • Michael Totten,

    Affiliation: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • Feng Cao,

    Affiliations: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America, Saint Louis University Liver Center, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • Eleftherios Michailidis,

    Affiliation: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, United States of America

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  • Rajeev Aurora,

    Affiliation: Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • Marvin J. Meyers,

    Affiliation: Center for World Health and Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • E. Jon Jacobsen,

    Affiliation: Center for World Health and Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America

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  • Michael A. Parniak,

    Affiliation: Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, United States of America

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  • Stefan G. Sarafianos

    Affiliation: Department of Molecular Microbiology and Immunology and Department of Biochemistry, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center, Columbia, Missouri, United States of America

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  • Published: January 22, 2013
  • DOI: 10.1371/journal.ppat.1003125

About the Authors

John E. Tavis, Xiaohong Cheng, Yuan Hu, Michael Totten, Feng Cao, Rajeev Aurora
Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
John E. Tavis, Feng Cao
Saint Louis University Liver Center, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
Yuan Hu
Key Laboratory of Molecular Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China
Eleftherios Michailidis, Michael A. Parniak
Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, United States of America
Marvin J. Meyers, E. Jon Jacobsen
Center for World Health and Medicine, Saint Louis University School of Medicine, Saint Louis, Missouri, United States of America
Stefan G. Sarafianos
Department of Molecular Microbiology and Immunology and Department of Biochemistry, University of Missouri School of Medicine, Christopher S. Bond Life Sciences Center, Columbia, Missouri, United States of America

Corresponding Author

Email: tavisje@slu.edu

Competing Interests

I have read the journal's policy and have the following conflicts: JET will be an inventor on a pending patent application covering this RNAseH assay and the compounds identified with it. SGS and MAP will be inventors on patent application(s) covering compounds #12-15. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JET YH FC EM RA MJM EJJ MAP SGS. Performed the experiments: JET XC YH MT FC EM. Analyzed the data: JET XC YH FC EM SGS. Contributed reagents/materials/analysis tools: JET RA MJM EJJ MAP SGS. Wrote the paper: JET YH SGS.