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Research Article

Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed against Three Antigenic Islands and Largely Contained in a CXCR3+CCR6+ Th1 Subset

  • Cecilia S. Lindestam Arlehamn,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • Anna Gerasimova,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • Federico Mele,

    Affiliation: Institute for Research in Biomedicine, Bellinzona, Switzerland

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  • Ryan Henderson,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • Justine Swann,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • Jason A. Greenbaum,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • Yohan Kim,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • John Sidney,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • Eddie A. James,

    Affiliation: Benaroya Research Institute, Seattle, Washington, United States of America

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  • Randy Taplitz,

    Affiliation: Antiviral Research Centre, University of California, San Diego, San Diego, California, United States of America

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  • Denise M. McKinney,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • William W. Kwok,

    Affiliation: Benaroya Research Institute, Seattle, Washington, United States of America

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  • Howard Grey,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • Federica Sallusto,

    Affiliation: Institute for Research in Biomedicine, Bellinzona, Switzerland

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  • Bjoern Peters,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • Alessandro Sette mail

    alex@liai.org

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • Published: January 24, 2013
  • DOI: 10.1371/journal.ppat.1003130

About the Authors

Cecilia S. Lindestam Arlehamn, Anna Gerasimova, Ryan Henderson, Justine Swann, Jason A. Greenbaum, Yohan Kim, John Sidney, Denise M. McKinney, Howard Grey, Bjoern Peters, Alessandro Sette
La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
Federico Mele, Federica Sallusto
Institute for Research in Biomedicine, Bellinzona, Switzerland
Eddie A. James, William W. Kwok
Benaroya Research Institute, Seattle, Washington, United States of America
Randy Taplitz
Antiviral Research Centre, University of California, San Diego, San Diego, California, United States of America

Corresponding Author

Email: alex@liai.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: C.S. Lindestam Arlehamn, A. Sette, A. Gerasimova, F. Mele, F. Sallusto, B. Peters, H. Grey. Performed the experiments: C.S. Lindestam Arlehamn, F. Mele, R. Henderson, J. Swann, J.A. Greenbaum, J. Sidney, D.M. McKinney. Analyzed the data: C.S. Lindestam Arlehamn, A. Gerasimova, F. Mele, Y. Kim. Contributed reagents/materials/analysis tools: E.A. James, R. Taplitz, W.W. Kwok. Wrote the paper: C.S. Lindestam Arlehamn, A. Sette, F. Sallusto. All authors discussed the results and implications and commented on the manuscript at all stages. Critically read and edited the manuscript: D.M. McKinney, H. Grey.