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Research Article

Schmallenberg Virus Pathogenesis, Tropism and Interaction with the Innate Immune System of the Host

  • Mariana Varela,

    Affiliation: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Esther Schnettler,

    Affiliation: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Marco Caporale,

    Affiliations: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Istituto G. Caporale, Teramo, Italy

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  • Claudio Murgia,

    Affiliation: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Gerald Barry,

    Affiliation: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Melanie McFarlane,

    Affiliation: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Eva McGregor,

    Affiliation: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Ilaria M. Piras,

    Affiliations: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Sassari, Italy

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  • Andrew Shaw,

    Affiliation: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Catherine Lamm,

    Affiliation: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Anna Janowicz,

    Affiliation: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Martin Beer,

    Affiliation: Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany

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  • Mandy Glass,

    Affiliation: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Vanessa Herder,

    Affiliation: Department of Pathology and Center of Systems Neuroscience, University of Veterinary Medicine, Hannover, Germany

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  • Kerstin Hahn,

    Affiliation: Department of Pathology and Center of Systems Neuroscience, University of Veterinary Medicine, Hannover, Germany

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  • Wolfgang Baumgärtner,

    Affiliation: Department of Pathology and Center of Systems Neuroscience, University of Veterinary Medicine, Hannover, Germany

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  • Alain Kohl,

    Affiliation: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Massimo Palmarini mail

    massimo.palmarini@glasgow.ac.uk

    Affiliation: MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

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  • Published: January 10, 2013
  • DOI: 10.1371/journal.ppat.1003133

About the Authors

Mariana Varela, Esther Schnettler, Marco Caporale, Claudio Murgia, Gerald Barry, Melanie McFarlane, Eva McGregor, Ilaria M. Piras, Andrew Shaw, Catherine Lamm, Anna Janowicz, Mandy Glass, Alain Kohl, Massimo Palmarini
MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Marco Caporale
Istituto G. Caporale, Teramo, Italy
Ilaria M. Piras
Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Sassari, Italy
Martin Beer
Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
Vanessa Herder, Kerstin Hahn, Wolfgang Baumgärtner
Department of Pathology and Center of Systems Neuroscience, University of Veterinary Medicine, Hannover, Germany

Corresponding Author

Email: massimo.palmarini@glasgow.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MV ES AK MP. Performed the experiments: MV ES MC CM GB MMcF EMcG IMP AS AJ MG. Analyzed the data: MV ES MC CM GB AS CL MB VH KH WB AK MP. Contributed reagents/materials/analysis tools: MB VH KH WB. Wrote the paper: MV AK MP.