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Research Article

Adhesion of Neisseria meningitidis to Dermal Vessels Leads to Local Vascular Damage and Purpura in a Humanized Mouse Model

  • Keira Melican,

    Affiliations: INSERM, U970, Paris Cardiovascular Research Center, Paris, France, Université Paris Descartes, Faculté de Médecine Paris Descartes, Paris, France

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  • Paula Michea Veloso,

    Affiliations: INSERM, U970, Paris Cardiovascular Research Center, Paris, France, Université Paris Descartes, Faculté de Médecine Paris Descartes, Paris, France

    Current address: Institut Curie, Department of Immunology, Paris, France

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  • Tiffany Martin,

    Affiliations: INSERM, U970, Paris Cardiovascular Research Center, Paris, France, Université Paris Descartes, Faculté de Médecine Paris Descartes, Paris, France

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  • Patrick Bruneval,

    Affiliations: INSERM, U970, Paris Cardiovascular Research Center, Paris, France, Université Paris Descartes, Faculté de Médecine Paris Descartes, Paris, France, AP-HP, Hôpital Européen Georges Pompidou, Paris, France

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  • Guillaume Duménil mail

    guillaume.dumenil@inserm.fr

    Affiliations: INSERM, U970, Paris Cardiovascular Research Center, Paris, France, Université Paris Descartes, Faculté de Médecine Paris Descartes, Paris, France

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  • Published: January 24, 2013
  • DOI: 10.1371/journal.ppat.1003139

About the Authors

Keira Melican, Paula Michea Veloso, Tiffany Martin, Patrick Bruneval, Guillaume Duménil
INSERM, U970, Paris Cardiovascular Research Center, Paris, France
Keira Melican, Paula Michea Veloso, Tiffany Martin, Patrick Bruneval, Guillaume Duménil
Université Paris Descartes, Faculté de Médecine Paris Descartes, Paris, France
Patrick Bruneval
AP-HP, Hôpital Européen Georges Pompidou, Paris, France

Corresponding Author

Email: guillaume.dumenil@inserm.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KM PMV GD. Performed the experiments: KM PMV TM. Analyzed the data: KM PMV TM PB GD. Contributed reagents/materials/analysis tools: PB GD. Wrote the paper: KM GD.