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Research Article

Point Mutations in FimH Adhesin of Crohn's Disease-Associated Adherent-Invasive Escherichia coli Enhance Intestinal Inflammatory Response

  • Nicolas Dreux,

    Affiliation: M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France

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  • Jérémy Denizot,

    Affiliation: M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France

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  • Margarita Martinez-Medina,

    Affiliation: M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France

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  • Alexander Mellmann,

    Affiliation: Institute of Hygiene, University Hospital Münster, Münster, Germany

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  • Maria Billig,

    Affiliation: University of Washington School of Medicine, Department of Microbiology, Seattle, Washington, United States of America

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  • Dagmara Kisiela,

    Affiliation: University of Washington School of Medicine, Department of Microbiology, Seattle, Washington, United States of America

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  • Sujay Chattopadhyay,

    Affiliation: University of Washington School of Medicine, Department of Microbiology, Seattle, Washington, United States of America

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  • Evgeni Sokurenko,

    Affiliation: University of Washington School of Medicine, Department of Microbiology, Seattle, Washington, United States of America

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  • Christel Neut,

    Affiliation: Inserm U995, Université Lille II, Hôpital Claude Huriez, Lille, France

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  • Corinne Gower-Rousseau,

    Affiliation: Inserm U995, Université Lille II, Hôpital Claude Huriez, Lille, France

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  • Jean-Frédéric Colombel,

    Affiliation: Inserm U995, Université Lille II, Hôpital Claude Huriez, Lille, France

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  • Richard Bonnet,

    Affiliations: M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France, Service de Bactériologie, CHU, Clermont-Ferrand, France

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  • Arlette Darfeuille-Michaud,

    Affiliations: M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France, Service de Bactériologie, CHU, Clermont-Ferrand, France, Institut Universitaire de Technologie, Génie Biologique, Aubière, France

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  • Nicolas Barnich mail

    nicolas.barnich@u-clermont1.fr

    Affiliations: M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France, Institut Universitaire de Technologie, Génie Biologique, Aubière, France

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  • Published: January 24, 2013
  • DOI: 10.1371/journal.ppat.1003141

About the Authors

Nicolas Dreux, Jérémy Denizot, Margarita Martinez-Medina, Richard Bonnet, Arlette Darfeuille-Michaud, Nicolas Barnich
M2iSH, UMR1071 Inserm, Université d'Auvergne, USC-INRA 2018, Clermont-Ferrand, France
Alexander Mellmann
Institute of Hygiene, University Hospital Münster, Münster, Germany
Maria Billig, Dagmara Kisiela, Sujay Chattopadhyay, Evgeni Sokurenko
University of Washington School of Medicine, Department of Microbiology, Seattle, Washington, United States of America
Christel Neut, Corinne Gower-Rousseau, Jean-Frédéric Colombel
Inserm U995, Université Lille II, Hôpital Claude Huriez, Lille, France
Richard Bonnet, Arlette Darfeuille-Michaud
Service de Bactériologie, CHU, Clermont-Ferrand, France
Arlette Darfeuille-Michaud, Nicolas Barnich
Institut Universitaire de Technologie, Génie Biologique, Aubière, France

Corresponding Author

Email: nicolas.barnich@u-clermont1.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ND AM ADM NB. Performed the experiments: ND JD MMM MB SC DK. Analyzed the data: ND ES RB ADM NB. Contributed reagents/materials/analysis tools: ES RB CN JFC CGR. Wrote the paper: ND JD ES ADM NB.