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Research Article

Plasmodium falciparum Malaria Elicits Inflammatory Responses that Dysregulate Placental Amino Acid Transport

  • Philippe Boeuf mail,

    pboeuf@unimelb.edu.au

    Affiliations: The University of Melbourne, Department of Medicine (RMH), Parkville, Victoria, Australia, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia

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  • Elizabeth H. Aitken,

    Affiliation: The University of Melbourne, Department of Medicine (RMH), Parkville, Victoria, Australia

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  • Upeksha Chandrasiri,

    Affiliation: The University of Melbourne, Department of Medicine (RMH), Parkville, Victoria, Australia

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  • Caroline Lin Lin Chua,

    Affiliation: The University of Melbourne, Department of Medicine (RMH), Parkville, Victoria, Australia

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  • Bernie McInerney,

    Affiliation: Australian Proteome Analysis Facility (APAF), Macquarie University, Sydney, New South Wales, Australia

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  • Leon McQuade,

    Affiliation: Australian Proteome Analysis Facility (APAF), Macquarie University, Sydney, New South Wales, Australia

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  • Michael Duffy,

    Affiliations: The University of Melbourne, Department of Medicine (RMH), Parkville, Victoria, Australia, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia

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  • Malcolm Molyneux,

    Affiliations: Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi, School of Tropical Medicine and University of Liverpool, Liverpool, United Kingdom

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  • Graham Brown,

    Affiliations: The University of Melbourne, Department of Medicine (RMH), Parkville, Victoria, Australia, The Nossal Institute for Global Health, The University of Melbourne, Parkville, Victoria, Australia

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  • Jocelyn Glazier,

    Affiliation: Maternal and Fetal Health Research Centre, University of Manchester, St. Mary's Hospital, Manchester, United Kingdom

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  • Stephen J. Rogerson

    Affiliations: The University of Melbourne, Department of Medicine (RMH), Parkville, Victoria, Australia, Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia

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  • Published: February 07, 2013
  • DOI: 10.1371/journal.ppat.1003153

About the Authors

Philippe Boeuf, Elizabeth H. Aitken, Upeksha Chandrasiri, Caroline Lin Lin Chua, Michael Duffy, Graham Brown, Stephen J. Rogerson
The University of Melbourne, Department of Medicine (RMH), Parkville, Victoria, Australia
Philippe Boeuf, Michael Duffy, Stephen J. Rogerson
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia
Bernie McInerney, Leon McQuade
Australian Proteome Analysis Facility (APAF), Macquarie University, Sydney, New South Wales, Australia
Malcolm Molyneux
Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
Malcolm Molyneux
School of Tropical Medicine and University of Liverpool, Liverpool, United Kingdom
Graham Brown
The Nossal Institute for Global Health, The University of Melbourne, Parkville, Victoria, Australia
Jocelyn Glazier
Maternal and Fetal Health Research Centre, University of Manchester, St. Mary's Hospital, Manchester, United Kingdom

Corresponding Author

Email: pboeuf@unimelb.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Obtained ethical clearance: MM SJR. Supervised sample collection: MM. Conceived and designed the experiments: PB EHA UC CLLC BM LM MD GB JG SJR. Performed the experiments: PB EHA UC CLLC BM LM MD. Analyzed the data: PB EHA UC CLLC BM LM JG SJR. Contributed reagents/materials/analysis tools: BM LM MD MM JG. Wrote the paper: PB JG SJR.