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Research Article

A Toxoplasma Palmitoyl Acyl Transferase and the Palmitoylated Armadillo Repeat Protein TgARO Govern Apical Rhoptry Tethering and Reveal a Critical Role for the Rhoptries in Host Cell Invasion but Not Egress

  • Josh R. Beck,

    Affiliation: Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, United States of America

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  • Connie Fung,

    Affiliation: Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, United States of America

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  • Kurtis W. Straub,

    Affiliation: Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, United States of America

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  • Isabelle Coppens,

    Affiliation: Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Ajay A. Vashisht,

    Affiliation: Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America

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  • James A. Wohlschlegel,

    Affiliation: Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America

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  • Peter J. Bradley mail

    pbradley@ucla.edu

    Affiliation: Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, United States of America

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  • Published: February 07, 2013
  • DOI: 10.1371/journal.ppat.1003162

About the Authors

Josh R. Beck, Connie Fung, Kurtis W. Straub, Peter J. Bradley
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, United States of America
Isabelle Coppens
Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America
Ajay A. Vashisht, James A. Wohlschlegel
Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, United States of America

Corresponding Author

Email: pbradley@ucla.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JRB PJB. Performed the experiments: JRB CF KWS IC AAV. Analyzed the data: JRB IC JAW PJB. Wrote the paper: JRB PJB.