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Research Article

A Refined Model of the Prototypical Salmonella SPI-1 T3SS Basal Body Reveals the Molecular Basis for Its Assembly

  • Julien R. C. Bergeron equal contributor,

    equal contributor Contributed equally to this work with: Julien R. C. Bergeron, Liam J. Worrall, Nikolaos G. Sgourakis

    Affiliation: Department of Biochemistry and Molecular Biology, and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada

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  • Liam J. Worrall equal contributor,

    equal contributor Contributed equally to this work with: Julien R. C. Bergeron, Liam J. Worrall, Nikolaos G. Sgourakis

    Affiliation: Department of Biochemistry and Molecular Biology, and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Nikolaos G. Sgourakis equal contributor,

    equal contributor Contributed equally to this work with: Julien R. C. Bergeron, Liam J. Worrall, Nikolaos G. Sgourakis

    Affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

    Current address: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

    X
  • Frank DiMaio,

    Affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

    X
  • Richard A. Pfuetzner,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

    X
  • Heather B. Felise,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

    Current address: Department of Biological Sciences, Moravian College, Bethlehem, Pennsylvania, United States of America.

    X
  • Marija Vuckovic,

    Affiliation: Department of Biochemistry and Molecular Biology, and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada

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  • Angel C. Yu,

    Affiliation: Department of Biochemistry and Molecular Biology, and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada

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  • Samuel I. Miller,

    Affiliations: Department of Microbiology, University of Washington, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America

    X
  • David Baker mail,

    dabaker@uw.edu (DB); ncjs@mail.ubc.ca (NCJS)

    Affiliations: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

    X
  • Natalie C. J. Strynadka mail

    dabaker@uw.edu (DB); ncjs@mail.ubc.ca (NCJS)

    Affiliation: Department of Biochemistry and Molecular Biology, and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Published: April 25, 2013
  • DOI: 10.1371/journal.ppat.1003307

About the Authors

Julien R. C. Bergeron, Liam J. Worrall, Marija Vuckovic, Angel C. Yu, Natalie C. J. Strynadka
Department of Biochemistry and Molecular Biology, and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada
Nikolaos G. Sgourakis, Frank DiMaio, David Baker
Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
Richard A. Pfuetzner, Heather B. Felise, Samuel I. Miller
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
Samuel I. Miller, David Baker
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
Samuel I. Miller
Department of Medicine, University of Washington, Seattle, Washington, United States of America
David Baker
Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JRCB LJW NGS DB NCJS. Performed the experiments: JRCB LJW NGS FDM RAP HBF MV ACY. Analyzed the data: JRCB LJW NGS DB NCJS. Contributed reagents/materials/analysis tools: SIM. Wrote the paper: JRCB LJW NGS DB NCJS.