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Research Article

Differences in Gastric Carcinoma Microenvironment Stratify According to EBV Infection Intensity: Implications for Possible Immune Adjuvant Therapy

  • Michael J. Strong equal contributor,

    equal contributor Contributed equally to this work with: Michael J. Strong, Guorong Xu

    Affiliations: Department of Pathology, Tulane University, New Orleans, Louisiana, United States of America, Tulane Cancer Center, New Orleans, Louisiana, United States of America

    X
  • Guorong Xu equal contributor,

    equal contributor Contributed equally to this work with: Michael J. Strong, Guorong Xu

    Affiliation: Department of Computer Science, University of New Orleans, New Orleans, Louisiana, United States of America

    X
  • Joseph Coco,

    Affiliation: Department of Computer Science, University of New Orleans, New Orleans, Louisiana, United States of America

    X
  • Carl Baribault,

    Affiliations: Tulane Cancer Center, New Orleans, Louisiana, United States of America, Department of Mathematics, Tulane University, New Orleans, Louisiana, United States of America

    X
  • Dass S. Vinay,

    Affiliation: Department of Medicine, Section of Clinical Immunology, Allergy, and Rheumatology, Tulane University, New Orleans, Louisiana, United States of America

    X
  • Michelle R. Lacey,

    Affiliations: Tulane Cancer Center, New Orleans, Louisiana, United States of America, Department of Mathematics, Tulane University, New Orleans, Louisiana, United States of America

    X
  • Amy L. Strong,

    Affiliation: Tulane Center for Stem Cell Research and Regenerative Medicine, New Orleans, Louisiana, United States of America

    X
  • Teresa A. Lehman,

    Affiliation: BioServe Biotechnologies, Ltd., Beltsville, Maryland, United States of America

    X
  • Michael B. Seddon,

    Affiliation: BioServe Biotechnologies, Ltd., Beltsville, Maryland, United States of America

    X
  • Zhen Lin,

    Affiliations: Department of Pathology, Tulane University, New Orleans, Louisiana, United States of America, Tulane Cancer Center, New Orleans, Louisiana, United States of America

    X
  • Monica Concha,

    Affiliations: Department of Pathology, Tulane University, New Orleans, Louisiana, United States of America, Tulane Cancer Center, New Orleans, Louisiana, United States of America

    X
  • Melody Baddoo,

    Affiliations: Department of Pathology, Tulane University, New Orleans, Louisiana, United States of America, Tulane Cancer Center, New Orleans, Louisiana, United States of America

    X
  • MaryBeth Ferris,

    Affiliation: Department of Microbiology & Immunology, Tulane University, New Orleans, Louisiana, United States of America

    X
  • Kenneth F. Swan,

    Affiliation: Department of Obstetrics and Gynecology, Tulane University, New Orleans, Louisiana, United States of America

    X
  • Deborah E. Sullivan,

    Affiliation: Department of Microbiology & Immunology, Tulane University, New Orleans, Louisiana, United States of America

    X
  • Matthew E. Burow,

    Affiliations: Tulane Cancer Center, New Orleans, Louisiana, United States of America, Department of Medicine, Section of Hematology and Medical Oncology, Tulane University, New Orleans, Louisiana, United States of America

    X
  • Christopher M. Taylor mail,

    ctay15@lsuhsc.edu (CMT); eflemin@tulane.edu (EKF)

    Affiliations: Department of Computer Science, University of New Orleans, New Orleans, Louisiana, United States of America, Department of Microbiology, Immunology & Parasitology, Louisiana State University School of Medicine, New Orleans, Louisiana, United States of America, Research Institute for Children, Children's Hospital, New Orleans, Louisiana, United States of America

    X
  • Erik K. Flemington mail

    ctay15@lsuhsc.edu (CMT); eflemin@tulane.edu (EKF)

    Affiliations: Department of Pathology, Tulane University, New Orleans, Louisiana, United States of America, Tulane Cancer Center, New Orleans, Louisiana, United States of America

    X
  • Published: May 09, 2013
  • DOI: 10.1371/journal.ppat.1003341

About the Authors

Michael J. Strong, Zhen Lin, Monica Concha, Melody Baddoo, Erik K. Flemington
Department of Pathology, Tulane University, New Orleans, Louisiana, United States of America
Michael J. Strong, Carl Baribault, Michelle R. Lacey, Zhen Lin, Monica Concha, Melody Baddoo, Matthew E. Burow, Erik K. Flemington
Tulane Cancer Center, New Orleans, Louisiana, United States of America
Guorong Xu, Joseph Coco, Christopher M. Taylor
Department of Computer Science, University of New Orleans, New Orleans, Louisiana, United States of America
Carl Baribault, Michelle R. Lacey
Department of Mathematics, Tulane University, New Orleans, Louisiana, United States of America
Dass S. Vinay
Department of Medicine, Section of Clinical Immunology, Allergy, and Rheumatology, Tulane University, New Orleans, Louisiana, United States of America
Amy L. Strong
Tulane Center for Stem Cell Research and Regenerative Medicine, New Orleans, Louisiana, United States of America
Teresa A. Lehman, Michael B. Seddon
BioServe Biotechnologies, Ltd., Beltsville, Maryland, United States of America
MaryBeth Ferris, Deborah E. Sullivan
Department of Microbiology & Immunology, Tulane University, New Orleans, Louisiana, United States of America
Kenneth F. Swan
Department of Obstetrics and Gynecology, Tulane University, New Orleans, Louisiana, United States of America
Matthew E. Burow
Department of Medicine, Section of Hematology and Medical Oncology, Tulane University, New Orleans, Louisiana, United States of America
Christopher M. Taylor
Department of Microbiology, Immunology & Parasitology, Louisiana State University School of Medicine, New Orleans, Louisiana, United States of America
Christopher M. Taylor
Research Institute for Children, Children's Hospital, New Orleans, Louisiana, United States of America

Corresponding Authors

Competing Interests

The authors, Teresa A. Lehman and Michael B. Seddon are currently under the employment of BioServe Biotechnologies, Ltd. BioServe Biotechnologies, Ltd provided funds, resources and equipment to conduct some of the studies and provided salary and benefits for Teresa A. Lehman and Michael B. Seddon. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MJS GX CMT EKF. Performed the experiments: MJS ALS TAL MBS. Analyzed the data: MJS CB DSV MRL ALS TAL MBS ZL MEB DES EKF. Contributed reagents/materials/analysis tools: MJS GX JC CB MRL ALS TAL MBS MC MB MF KFS CMT. Wrote the paper: MJS EKF.