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Research Article

Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α Specificity

  • Kevin R. McCarthy,

    Affiliations: Harvard Program in Virology, Harvard Medical School, Boston, Massachusetts, United States of America, Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America

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  • Aaron G. Schmidt,

    Affiliation: Laboratory of Molecular Medicine, Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Andrea Kirmaier,

    Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America

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  • Allison L. Wyand,

    Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America

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  • Ruchi M. Newman,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Welkin E. Johnson mail

    welkin.johnson@bc.edu

    Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America

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  • Published: May 09, 2013
  • DOI: 10.1371/journal.ppat.1003352

About the Authors

Kevin R. McCarthy
Harvard Program in Virology, Harvard Medical School, Boston, Massachusetts, United States of America
Kevin R. McCarthy, Andrea Kirmaier, Allison L. Wyand, Welkin E. Johnson
Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America
Aaron G. Schmidt
Laboratory of Molecular Medicine, Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Ruchi M. Newman
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: welkin.johnson@bc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KRM AGS WEJ. Performed the experiments: KRM AGS AK ALW RMN. Analyzed the data: KRM AGS AK RMN WEJ. Contributed reagents/materials/analysis tools: KRM AGS AK RMN WEJ. Wrote the paper: KRM AGS WEJ.