Advertisement
Research Article

Antigenic Drift of the Pandemic 2009 A(H1N1) Influenza Virus in a Ferret Model

  • Teagan Guarnaccia,

    Affiliations: WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia, Monash University, School of Applied Sciences, Churchill, Victoria, Australia

    X
  • Louise A. Carolan,

    Affiliation: WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia

    X
  • Sebastian Maurer-Stroh,

    Affiliations: Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore, National Public Health Laboratory, Communicable Diseases Division Ministry of Health, Singapore, School of Biological Sciences (SBS), Nanyang Technological University (NTU), Singapore

    X
  • Raphael T. C. Lee,

    Affiliation: Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore

    X
  • Emma Job,

    Affiliation: The University of Melbourne, Department Microbiology & Immunology, Melbourne, Victoria, Australia

    X
  • Patrick C. Reading,

    Affiliations: WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia, The University of Melbourne, Department Microbiology & Immunology, Melbourne, Victoria, Australia

    X
  • Stephen Petrie,

    Affiliation: The University of Melbourne, Melbourne School of Population Health, Melbourne, Victoria, Australia

    X
  • James M. McCaw,

    Affiliations: The University of Melbourne, Melbourne School of Population Health, Melbourne, Victoria, Australia, Royal Children's Hospital, Murdoch Childrens Research Institute, Vaccine and Immunisation Research Group, Melbourne, Victoria, Australia

    X
  • Jodie McVernon,

    Affiliations: The University of Melbourne, Melbourne School of Population Health, Melbourne, Victoria, Australia, Royal Children's Hospital, Murdoch Childrens Research Institute, Vaccine and Immunisation Research Group, Melbourne, Victoria, Australia

    X
  • Aeron C. Hurt,

    Affiliations: WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia, Monash University, School of Applied Sciences, Churchill, Victoria, Australia

    X
  • Anne Kelso,

    Affiliation: WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia

    X
  • Jennifer Mosse,

    Affiliation: Monash University, School of Applied Sciences, Churchill, Victoria, Australia

    X
  • Ian G. Barr,

    Affiliation: WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia

    X
  • Karen L. Laurie mail

    Karen.Laurie@influenzacentre.org

    Affiliations: WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia, Monash University, School of Applied Sciences, Churchill, Victoria, Australia, The University of Melbourne, Department Microbiology & Immunology, Melbourne, Victoria, Australia

    X
  • Published: May 09, 2013
  • DOI: 10.1371/journal.ppat.1003354

About the Authors

Teagan Guarnaccia, Louise A. Carolan, Patrick C. Reading, Aeron C. Hurt, Anne Kelso, Ian G. Barr, Karen L. Laurie
WHO Collaborating Centre for Reference and Research on Influenza, Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia
Teagan Guarnaccia, Aeron C. Hurt, Jennifer Mosse, Karen L. Laurie
Monash University, School of Applied Sciences, Churchill, Victoria, Australia
Sebastian Maurer-Stroh, Raphael T. C. Lee
Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore
Sebastian Maurer-Stroh
National Public Health Laboratory, Communicable Diseases Division Ministry of Health, Singapore
Sebastian Maurer-Stroh
School of Biological Sciences (SBS), Nanyang Technological University (NTU), Singapore
Emma Job, Patrick C. Reading, Karen L. Laurie
The University of Melbourne, Department Microbiology & Immunology, Melbourne, Victoria, Australia
Stephen Petrie, James M. McCaw, Jodie McVernon
The University of Melbourne, Melbourne School of Population Health, Melbourne, Victoria, Australia
James M. McCaw, Jodie McVernon
Royal Children's Hospital, Murdoch Childrens Research Institute, Vaccine and Immunisation Research Group, Melbourne, Victoria, Australia

Corresponding Author

Email: Karen.Laurie@influenzacentre.org

Competing Interests

The WHO Collaborating Centre for Reference and Research on Influenza has or has previously had collaborative agreements with the International Federation of Pharmaceutical and Manufacturers Associations, Novartis Vaccines & Diagnostics and CSL unrelated to this study. A. Kelso owns shares in CSL. J. McVernon has been a co-investigator on influenza vaccine studies sponsored by CSL, Sanofi and Novartis vaccines. She has received travel grants and honoraria from Novartis vaccines to support scientific presentations at meetings and conferences, and to sit on advisory boards. S. Maurer-Stroh, R.T.C. Lee, E. Job, S. Petrie, J.M. McCaw, and J. Mosse have no competing interests to declare. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: T. Guarnaccia, S. Maurer-Stroh, R.T.C. Lee, P.C. Reading, J.M. McCaw, J. McVernon, I.G. Barr, K.L. Laurie. Performed the experiments: T. Guarnaccia, L.A. Carolan, S. Maurer-Stroh, R.T.C. Lee, E. Job, A.C. Hurt, K.L. Laurie. Analyzed the data: T. Guarnaccia, S. Maurer-Stroh, R.T.C. Lee, S. Petrie, J.M. McCaw, J. McVernon, A.C. Hurt, J. Mosse, K.L. Laurie. Contributed reagents/materials/analysis tools: P.C. Reading, S. Maurer-Stroh, R.T.C. Lee. Wrote the paper: T. Guranaccia, L.A. Carolan, S. Maurer-Stroh, R.T.C. Lee, E. Job, P.C. Reading, S. Petrie, J.M. McCaw, J. McVernon, A.C. Hurt, A. Kelso, J. Mosse, I.G. Barr, K.L. Laurie.