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Research Article

Asexual Populations of the Human Malaria Parasite, Plasmodium falciparum, Use a Two-Step Genomic Strategy to Acquire Accurate, Beneficial DNA Amplifications

  • Jennifer L. Guler equal contributor,

    equal contributor Contributed equally to this work with: Jennifer L. Guler, Daniel L. Freeman

    Affiliation: Departments of Chemistry and Global Health, University of Washington, Seattle, Washington, United States of America

    Current address: Department of Biology, University of Virginia, Charlottesville, Virginia, United States of America.

    X
  • Daniel L. Freeman equal contributor,

    equal contributor Contributed equally to this work with: Jennifer L. Guler, Daniel L. Freeman

    Affiliation: Departments of Chemistry and Global Health, University of Washington, Seattle, Washington, United States of America

    Current address: Intellectual Ventures, Bellevue, Washington, United States of America.

    X
  • Vida Ahyong,

    Affiliation: Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America

    X
  • Rapatbhorn Patrapuvich,

    Affiliation: Departments of Chemistry and Global Health, University of Washington, Seattle, Washington, United States of America

    X
  • John White,

    Affiliation: Departments of Chemistry and Global Health, University of Washington, Seattle, Washington, United States of America

    X
  • Ramesh Gujjar,

    Affiliation: Departments of Chemistry and Global Health, University of Washington, Seattle, Washington, United States of America

    Current address: Organix, Inc., Woburn, Massachusetts, United States of America.

    X
  • Margaret A. Phillips,

    Affiliation: Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

    X
  • Joseph DeRisi,

    Affiliation: Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America

    X
  • Pradipsinh K. Rathod mail

    rathod@chem.washington.edu

    Affiliation: Departments of Chemistry and Global Health, University of Washington, Seattle, Washington, United States of America

    X
  • Published: May 23, 2013
  • DOI: 10.1371/journal.ppat.1003375

About the Authors

Jennifer L. Guler, Daniel L. Freeman, Rapatbhorn Patrapuvich, John White, Ramesh Gujjar, Pradipsinh K. Rathod
Departments of Chemistry and Global Health, University of Washington, Seattle, Washington, United States of America
Vida Ahyong, Joseph DeRisi
Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America
Margaret A. Phillips
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

Corresponding Author

Email: rathod@chem.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JLG DLF JW MAP PKR. Performed the experiments: JLG DLF VA RP JW RG. Analyzed the data: JLG DLF VA RP. Contributed reagents/materials/analysis tools: PKR JD MAP. Wrote the paper: JLG DLF PKR.