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Research Article

Dual Pili Post-translational Modifications Synergize to Mediate Meningococcal Adherence to Platelet Activating Factor Receptor on Human Airway Cells

  • Freda E. C. Jen equal contributor,

    equal contributor Contributed equally to this work with: Freda E. C. Jen, Matthew J. Warren

    Affiliation: Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia

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  • Matthew J. Warren equal contributor,

    equal contributor Contributed equally to this work with: Freda E. C. Jen, Matthew J. Warren

    Affiliation: School of Chemistry Molecular Biosciences, University of Queensland, St Lucia, Brisbane, Queensland, Australia

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  • Benjamin L. Schulz,

    Affiliation: School of Chemistry Molecular Biosciences, University of Queensland, St Lucia, Brisbane, Queensland, Australia

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  • Peter M. Power,

    Affiliation: Molecular Infectious Diseases Group, Department of Paediatrics, Weatherall Institute for Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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  • W. Edward Swords,

    Affiliation: Department of Microbiology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

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  • Jeffery N. Weiser,

    Affiliation: Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Michael A. Apicella,

    Affiliation: Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America

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  • Jennifer L. Edwards mail,

    jennifer.edwards@nationwidechildrens.org (JLE); m.jennings@griffith.edu.au (MPJ)

    Affiliation: The Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital and the Department of Pediatrics, The Ohio State University, Columbus, Ohio, United States of America

    Jennifer L. Edwards and Michael P. Jennings are joint senior authors.

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  • Michael P. Jennings mail

    jennifer.edwards@nationwidechildrens.org (JLE); m.jennings@griffith.edu.au (MPJ)

    Affiliation: Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia

    Jennifer L. Edwards and Michael P. Jennings are joint senior authors.

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  • Published: May 16, 2013
  • DOI: 10.1371/journal.ppat.1003377

About the Authors

Freda E. C. Jen, Michael P. Jennings
Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia
Matthew J. Warren, Benjamin L. Schulz
School of Chemistry Molecular Biosciences, University of Queensland, St Lucia, Brisbane, Queensland, Australia
Peter M. Power
Molecular Infectious Diseases Group, Department of Paediatrics, Weatherall Institute for Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
W. Edward Swords
Department of Microbiology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America
Jeffery N. Weiser
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Michael A. Apicella
Department of Microbiology, University of Iowa, Iowa City, Iowa, United States of America
Jennifer L. Edwards
The Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital and the Department of Pediatrics, The Ohio State University, Columbus, Ohio, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FECJ MJW BLS WES JNW MAA JLE MPJ. Performed the experiments: FECJ MJW BLS WES PMP JNW MAA JLE MPJ. Analyzed the data: FECJ MJW BLS WES PMP JNW MAA JLE MPJ. Contributed reagents/materials/analysis tools: WES JNW MAA JLE MPJ. Wrote the paper: FECJ JLE MPJ.