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Research Article

DNA Methylation Impacts Gene Expression and Ensures Hypoxic Survival of Mycobacterium tuberculosis

  • Scarlet S. Shell,

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Erin G. Prestwich,

    Affiliation: Department of Biological Engineering and Center for Environmental Health Studies, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Seung-Hun Baek,

    Affiliation: Department of Microbiology & Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Rupal R. Shah,

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Christopher M. Sassetti,

    Affiliation: Department of Microbiology & Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Peter C. Dedon,

    Affiliation: Department of Biological Engineering and Center for Environmental Health Studies, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Sarah M. Fortune mail

    sfortune@hsph.harvard.edu

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

    X
  • Published: July 04, 2013
  • DOI: 10.1371/journal.ppat.1003419

About the Authors

Scarlet S. Shell, Rupal R. Shah, Sarah M. Fortune
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
Erin G. Prestwich, Peter C. Dedon
Department of Biological Engineering and Center for Environmental Health Studies, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Seung-Hun Baek, Christopher M. Sassetti
Department of Microbiology & Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Corresponding Author

Email: sfortune@hsph.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SSS EGP SHB CMS PCD SMF. Performed the experiments: SSS EGP SHB RRS. Analyzed the data: SSS EGP SHB RRS CMS PCD SMF. Wrote the paper: SSS SMF.