Advertisement
Research Article

Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)

  • Aravindan Ilangovan,

    Affiliations: Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Pharmacy, University of Nottingham, University Park, Nottingham, United Kingdom

    Current address: Research Department of Structural & Molecular Biology, Birkbeck and University College, London, United Kingdom.

    X
  • Matthew Fletcher,

    Affiliations: Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Giordano Rampioni,

    Affiliations: Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    Current address: Dept. of Biology, University of Roma Tre, Rome, Italy.

    X
  • Christian Pustelny,

    Affiliations: Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    Current address: Helmholtz Center for Infection Research, Braunschweig, Germany.

    X
  • Kendra Rumbaugh,

    Affiliation: Department of Surgery, University of Texas, Lubbock, Texas, United States of America

    X
  • Stephan Heeb,

    Affiliations: Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Miguel Cámara,

    Affiliations: Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Alex Truman,

    Affiliations: Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Siri Ram Chhabra,

    Affiliations: Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Jonas Emsley,

    Affiliations: Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Pharmacy, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Paul Williams mail

    paul.williams@nottingham.ac.uk

    Affiliations: Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom, School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom

    X
  • Published: July 25, 2013
  • DOI: 10.1371/journal.ppat.1003508

About the Authors

Aravindan Ilangovan, Matthew Fletcher, Giordano Rampioni, Christian Pustelny, Stephan Heeb, Miguel Cámara, Alex Truman, Siri Ram Chhabra, Jonas Emsley, Paul Williams
Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
Aravindan Ilangovan, Matthew Fletcher, Giordano Rampioni, Christian Pustelny, Stephan Heeb, Miguel Cámara, Alex Truman, Siri Ram Chhabra, Paul Williams
School of Molecular Medical Sciences, University of Nottingham, University Park, Nottingham, United Kingdom
Aravindan Ilangovan, Jonas Emsley
School of Pharmacy, University of Nottingham, University Park, Nottingham, United Kingdom
Kendra Rumbaugh
Department of Surgery, University of Texas, Lubbock, Texas, United States of America

Corresponding Author

Email: paul.williams@nottingham.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PW JE GR SRC. Performed the experiments: AI MF GR CP KR AT. Analyzed the data: AI JE MF GR CP KR SH MC SRC PW. Contributed reagents/materials/analysis tools: AT. Wrote the paper: PW JE SH.