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Research Article

SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens

  • Ho Pan Sham,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Emily Yi Shan Yu,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Muhammet F. Gulen,

    Affiliation: Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

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  • Ganive Bhinder,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Martin Stahl,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Justin M. Chan,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Lara Brewster,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Vijay Morampudi,

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

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  • Deanna L. Gibson,

    Affiliation: Department of Biology, University of British Columbia Okanagan, Kelowna, British Columbia, Canada

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  • Michael R. Hughes,

    Affiliation: Department of Medical Genetics, Biomedical Research Center, University of British Columbia, Vancouver, British Columbia, Canada

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  • Kelly M. McNagny,

    Affiliation: Department of Medical Genetics, Biomedical Research Center, University of British Columbia, Vancouver, British Columbia, Canada

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  • Xiaoxia Li mail,

    lix@ccf.org (XL); bvallance@cw.bc.ca (BAV)

    Affiliation: Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America

    X
  • Bruce A. Vallance mail

    lix@ccf.org (XL); bvallance@cw.bc.ca (BAV)

    Affiliation: Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada

    X
  • Published: August 08, 2013
  • DOI: 10.1371/journal.ppat.1003539

About the Authors

Ho Pan Sham, Emily Yi Shan Yu, Ganive Bhinder, Martin Stahl, Justin M. Chan, Lara Brewster, Vijay Morampudi, Bruce A. Vallance
Division of Gastroenterology, BC's Children's Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, British Columbia, Canada
Muhammet F. Gulen, Xiaoxia Li
Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America
Deanna L. Gibson
Department of Biology, University of British Columbia Okanagan, Kelowna, British Columbia, Canada
Michael R. Hughes, Kelly M. McNagny
Department of Medical Genetics, Biomedical Research Center, University of British Columbia, Vancouver, British Columbia, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HPS BAV. Performed the experiments: HPS EYSY GB MS JMC LB VM. Analyzed the data: HPS MS BAV. Contributed reagents/materials/analysis tools: HPS MFG MS DLG MRH KMM XL. Wrote the paper: HPS BAV.