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Research Article

Immunization against a Saccharide Epitope Accelerates Clearance of Experimental Gonococcal Infection

  • Sunita Gulati,

    Affiliation: Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Bo Zheng,

    Affiliation: Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • George W. Reed,

    Affiliation: Department of Medicine, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Xiaohong Su,

    Affiliations: Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, People's Republic of China

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  • Andrew D. Cox,

    Affiliation: Vaccine Program, Human Health Therapeutics Portfolio, National Research Council Canada, Ottawa, Ontario, Canada

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  • Frank St. Michael,

    Affiliation: Vaccine Program, Human Health Therapeutics Portfolio, National Research Council Canada, Ottawa, Ontario, Canada

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  • Jacek Stupak,

    Affiliation: Vaccine Program, Human Health Therapeutics Portfolio, National Research Council Canada, Ottawa, Ontario, Canada

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  • Lisa A. Lewis,

    Affiliation: Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Sanjay Ram,

    Affiliation: Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Peter A. Rice mail

    Peter.Rice@umassmed.edu

    Affiliation: Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Published: August 29, 2013
  • DOI: 10.1371/journal.ppat.1003559

About the Authors

Sunita Gulati, Bo Zheng, Xiaohong Su, Lisa A. Lewis, Sanjay Ram, Peter A. Rice
Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
George W. Reed
Department of Medicine, Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Xiaohong Su
Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, People's Republic of China
Andrew D. Cox, Frank St. Michael, Jacek Stupak
Vaccine Program, Human Health Therapeutics Portfolio, National Research Council Canada, Ottawa, Ontario, Canada

Corresponding Author

Email: Peter.Rice@umassmed.edu

Competing Interests

We have read the journal's policy and disclose the following potential conflicts: SG and PAR are co-inventors on U.S. Patents 7,189, 405 and 7,871,628; “Peptide mimics of conserved gonococcal epitopes and methods and compostions using them”. The University of Masachusetts (Medical School) is the assignee on both of these issued patents and several related foreign patents and one foreign patent application. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SG GWR ADC LAL SR PAR. Performed the experiments: SG BZ FSM JS LAL. Analyzed the data: SG GWR XS ADC LAL SR PAR. Contributed reagents/materials/analysis tools: SG GWR ADC FSM JS LAL SR PAR. Wrote the paper: SG GWR LAL SR PAR.