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Research Article

TRIM5 alpha Drives SIVsmm Evolution in Rhesus Macaques

  • Fan Wu,

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Andrea Kirmaier,

    Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America

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  • Robert Goeken,

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Ilnour Ourmanov,

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Laura Hall,

    Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America

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  • Jennifer S. Morgan,

    Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America

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  • Kenta Matsuda,

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Alicia Buckler-White,

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Keiko Tomioka,

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Ronald Plishka,

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Sonya Whitted,

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Welkin Johnson,

    Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America

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  • Vanessa M. Hirsch mail

    vhirsch@niaid.nih.gov

    Affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: August 22, 2013
  • DOI: 10.1371/journal.ppat.1003577

About the Authors

Fan Wu, Robert Goeken, Ilnour Ourmanov, Kenta Matsuda, Alicia Buckler-White, Keiko Tomioka, Ronald Plishka, Sonya Whitted, Vanessa M. Hirsch
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Andrea Kirmaier, Laura Hall, Jennifer S. Morgan, Welkin Johnson
Biology Department, Boston College, Chestnut Hill, Massachusetts, United States of America

Corresponding Author

Email: vhirsch@niaid.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FW VMH WJ. Performed the experiments: FW RG SW AK JSM ABW RP KT IO KM LH. Analyzed the data: FW AK VMH WJ. Contributed reagents/materials/analysis tools: RG SW IO KM. Wrote the paper: FW VMH.