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Research Article

Real-Time Whole-Body Visualization of Chikungunya Virus Infection and Host Interferon Response in Zebrafish

  • Nuno Palha,

    Affiliations: Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris, France, CNRS URA2578, Paris, France, Université Pierre et Marie Curie, Paris, France

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  • Florence Guivel-Benhassine,

    Affiliations: Institut Pasteur, Virus et Immunité, Department of Virology, Paris, France, CNRS URA3015, Paris, France

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  • Valérie Briolat,

    Affiliations: Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris, France, CNRS URA2578, Paris, France

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  • Georges Lutfalla,

    Affiliations: CNRS UMR5235, Dynamiques des Interactions Membranaires et Pathologiques, Montpellier, France, Université Montpellier II, Montpellier, France

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  • Marion Sourisseau,

    Affiliations: Institut Pasteur, Virus et Immunité, Department of Virology, Paris, France, CNRS URA3015, Paris, France

    Current address: Mount Sinai School of Medicine, New York, New York, United States of America.

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  • Felix Ellett,

    Affiliation: Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia

    Current address: MRC Centre for Developmental and Biomedical Genetics, Sheffield, United Kingdom.

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  • Chieh-Huei Wang,

    Affiliation: Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia

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  • Graham J. Lieschke,

    Affiliation: Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia

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  • Philippe Herbomel,

    Affiliations: Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris, France, CNRS URA2578, Paris, France

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  • Olivier Schwartz,

    Affiliations: Institut Pasteur, Virus et Immunité, Department of Virology, Paris, France, CNRS URA3015, Paris, France

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  • Jean-Pierre Levraud mail

    jean-pierre.levraud@pasteur.fr

    Affiliations: Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris, France, CNRS URA2578, Paris, France

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  • Published: September 05, 2013
  • DOI: 10.1371/journal.ppat.1003619

About the Authors

Nuno Palha, Valérie Briolat, Philippe Herbomel, Jean-Pierre Levraud
Institut Pasteur, Macrophages et Développement de l'Immunité, Department of Developmental and Stem Cells Biology, Paris, France
Nuno Palha, Valérie Briolat, Philippe Herbomel, Jean-Pierre Levraud
CNRS URA2578, Paris, France
Nuno Palha
Université Pierre et Marie Curie, Paris, France
Florence Guivel-Benhassine, Marion Sourisseau, Olivier Schwartz
Institut Pasteur, Virus et Immunité, Department of Virology, Paris, France
Florence Guivel-Benhassine, Marion Sourisseau, Olivier Schwartz
CNRS URA3015, Paris, France
Georges Lutfalla
CNRS UMR5235, Dynamiques des Interactions Membranaires et Pathologiques, Montpellier, France
Georges Lutfalla
Université Montpellier II, Montpellier, France
Felix Ellett, Chieh-Huei Wang, Graham J. Lieschke
Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia

Corresponding Author

Email: jean-pierre.levraud@pasteur.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JPL OS NP. Performed the experiments: NP JPL FGB MS GL VB CHW. Analyzed the data: NP JPL OS PH. Contributed reagents/materials/analysis tools: FE GJL. Wrote the paper: NP JPL OS.