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Research Article

Ebola Virus RNA Editing Depends on the Primary Editing Site Sequence and an Upstream Secondary Structure

  • Masfique Mehedi,

    Affiliations: Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada, Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

    Current address: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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  • Thomas Hoenen,

    Affiliation: Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Shelly Robertson,

    Affiliation: Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Stacy Ricklefs,

    Affiliation: Research Technology Branch, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Michael A. Dolan,

    Affiliation: Bioinformatics and Computational Bioscience Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Travis Taylor,

    Affiliation: Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

    Current address: The University of Toledo, Health Education Building, Toledo, Ohio, United States of America.

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  • Darryl Falzarano,

    Affiliation: Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Hideki Ebihara,

    Affiliation: Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Stephen F. Porcella,

    Affiliation: Research Technology Branch, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Heinz Feldmann mail

    feldmannh@niaid.nih.gov

    Affiliations: Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada, Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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  • Published: October 17, 2013
  • DOI: 10.1371/journal.ppat.1003677

About the Authors

Masfique Mehedi, Heinz Feldmann
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
Masfique Mehedi, Thomas Hoenen, Shelly Robertson, Travis Taylor, Darryl Falzarano, Hideki Ebihara, Heinz Feldmann
Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
Stacy Ricklefs, Stephen F. Porcella
Research Technology Branch, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
Michael A. Dolan
Bioinformatics and Computational Bioscience Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: feldmannh@niaid.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MM TH HE SFP HF. Performed the experiments: MM TH SRi SRo TT. Analyzed the data: MM TH SRi SRo MAD TT DF HE SFP HF. Contributed reagents/materials/analysis tools: HE SFP. Wrote the paper: MM TH MAD HE SFP HF.