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Research Article

A Structure-Guided Mutation in the Major Capsid Protein Retargets BK Polyomavirus

  • Ursula Neu equal contributor,

    equal contributor Contributed equally to this work with: Ursula Neu, Stacy-ann A. Allen

    Affiliation: Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany

    Current address: National Institute of Medical Research, The Ridgeway, Mill Hill, London, United Kingdom.

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  • Stacy-ann A. Allen equal contributor,

    equal contributor Contributed equally to this work with: Ursula Neu, Stacy-ann A. Allen

    Affiliation: Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America

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  • Bärbel S. Blaum,

    Affiliations: Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany, Department of Chemistry, University of Luebeck, Luebeck, Germany

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  • Yan Liu,

    Affiliation: Glycosciences Laboratory, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Martin Frank,

    Affiliation: Biognos AB, Gothenburg, Sweden

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  • Angelina S. Palma,

    Affiliation: Glycosciences Laboratory, Faculty of Medicine, Imperial College London, London, United Kingdom

    Current address: REQUIMTE, CQFB, Faculty of Science and Technology /UNL, Caparica, Portugal.

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  • Luisa J. Ströh,

    Affiliation: Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany

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  • Ten Feizi,

    Affiliation: Glycosciences Laboratory, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Thomas Peters,

    Affiliation: Department of Chemistry, University of Luebeck, Luebeck, Germany

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  • Walter J. Atwood mail,

    walter_atwood@brown.edu (WJA); thilo.stehle@uni-tuebingen.de (TS)

    Affiliation: Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America

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  • Thilo Stehle mail

    walter_atwood@brown.edu (WJA); thilo.stehle@uni-tuebingen.de (TS)

    Affiliations: Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Published: October 10, 2013
  • DOI: 10.1371/journal.ppat.1003688

About the Authors

Ursula Neu, Bärbel S. Blaum, Luisa J. Ströh, Thilo Stehle
Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany
Stacy-ann A. Allen, Walter J. Atwood
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America
Bärbel S. Blaum, Thomas Peters
Department of Chemistry, University of Luebeck, Luebeck, Germany
Yan Liu, Angelina S. Palma, Ten Feizi
Glycosciences Laboratory, Faculty of Medicine, Imperial College London, London, United Kingdom
Martin Frank
Biognos AB, Gothenburg, Sweden
Thilo Stehle
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist. Dr. Martin Frank is employed by a company, Biognos AB in Gothenburg, Sweden. He declares that he does not have any financial, non-financial, professional or personal competing interests. His employment does not alter his and the other authors' adherence to all the PLOS PLoS Pathogens policies on sharing data and materials (as outlined in the guide for authors).

Author Contributions

Conceived and designed the experiments: UN SAA BSB YL MF ASP TF WJA TS. Performed the experiments: UN SAA BSB YL MF ASP LJS. Analyzed the data: UN SAA BSB YL MF ASP LJS TF TP WJA TS. Wrote the paper: UN SAA BSB YL MF ASP TF WJA TS.