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Research Article

A Small Molecule Glycosaminoglycan Mimetic Blocks Plasmodium Invasion of the Mosquito Midgut

  • Derrick K. Mathias equal contributor,

    equal contributor Contributed equally to this work with: Derrick K. Mathias, Rebecca Pastrana-Mena

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Rebecca Pastrana-Mena equal contributor,

    equal contributor Contributed equally to this work with: Derrick K. Mathias, Rebecca Pastrana-Mena

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Elisabetta Ranucci,

    Affiliation: Department of Chemistry, University of Milan, Milan, Italy

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  • Dingyin Tao,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Paolo Ferruti,

    Affiliation: Department of Chemistry, University of Milan, Milan, Italy

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  • Corrie Ortega,

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Gregory O. Staples,

    Affiliation: Department of Biochemistry and Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Joseph Zaia,

    Affiliation: Department of Biochemistry and Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, Massachusetts, United States of America

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  • Eizo Takashima,

    Affiliation: Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Ehime, Japan

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  • Takafumi Tsuboi,

    Affiliation: Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Ehime, Japan

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  • Natalie A. Borg,

    Affiliation: Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia

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  • Luisella Verotta,

    Affiliation: Department of Chemistry, University of Milan, Milan, Italy

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  • Rhoel R. Dinglasan mail

    rdinglas@jhsph.edu

    Affiliation: W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

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  • Published: November 21, 2013
  • DOI: 10.1371/journal.ppat.1003757

About the Authors

Derrick K. Mathias, Rebecca Pastrana-Mena, Dingyin Tao, Corrie Ortega, Rhoel R. Dinglasan
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
Elisabetta Ranucci, Paolo Ferruti, Luisella Verotta
Department of Chemistry, University of Milan, Milan, Italy
Gregory O. Staples, Joseph Zaia
Department of Biochemistry and Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, Massachusetts, United States of America
Eizo Takashima, Takafumi Tsuboi
Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Ehime, Japan
Natalie A. Borg
Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, Victoria, Australia

Corresponding Author

Email: rdinglas@jhsph.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DKM RPM ER DT JZ TT LV RRD. Performed the experiments: DKM RPM DT ER CO PF ET GOS NAB RRD. Analyzed the data: DKM RPM DT GOS JZ TT NAB LV RRD. Contributed reagents/materials/analysis tools: ER JZ TT LV. Wrote the paper: DKM RPM DT CO JZ TT NAB LV RRD.