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Research Article

Killer Bee Molecules: Antimicrobial Peptides as Effector Molecules to Target Sporogonic Stages of Plasmodium

  • Victoria Carter,

    Affiliation: Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Keele, Staffordshire, United Kingdom

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  • Ann Underhill,

    Affiliation: Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Keele, Staffordshire, United Kingdom

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  • Ibrahima Baber,

    Affiliation: Malaria Research and Training Centre (MRTC), Université des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali

    X
  • Lakamy Sylla,

    Affiliation: Malaria Research and Training Centre (MRTC), Université des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali

    X
  • Mounirou Baby,

    Affiliation: Centre National de Transfusion Sanguine, Bamako, Mali

    X
  • Isabelle Larget-Thiery,

    Affiliation: Institut Pasteur, Centre for Production and Infection of Anopheles (CEPIA), Parasitology and Mycology Department, Paris, France

    X
  • Agnès Zettor,

    Affiliation: Institut Pasteur, Centre for Production and Infection of Anopheles (CEPIA), Parasitology and Mycology Department, Paris, France

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  • Catherine Bourgouin,

    Affiliation: Institut Pasteur, Centre for Production and Infection of Anopheles (CEPIA), Parasitology and Mycology Department, Paris, France

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  • Ülo Langel,

    Affiliation: Department of Neurochemistry Svante Arrhenius v. 21A, Stockholm University, Stockholm, Sweden

    X
  • Ingrid Faye,

    Affiliation: Department of Molecular Bioscience, the Wenner-Gren Institute, Svante Arrhenius v. 20C, Stockholm University, Stockholm, Sweden

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  • Laszlo Otvos,

    Affiliation: Temple University Department of Biology, Philadelphia, Pennsylvania, United States of America

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  • John D. Wade,

    Affiliation: Howard Florey Research Laboratories, Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia

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  • Mamadou B. Coulibaly,

    Affiliation: Malaria Research and Training Centre (MRTC), Université des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali

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  • Sekou F. Traore,

    Affiliation: Malaria Research and Training Centre (MRTC), Université des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali

    X
  • Frederic Tripet,

    Affiliation: Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Keele, Staffordshire, United Kingdom

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  • Paul Eggleston mail,

    p.eggleston@keele.ac.uk

    Affiliation: Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Keele, Staffordshire, United Kingdom

    X
  • Hilary Hurd

    Affiliation: Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Keele, Staffordshire, United Kingdom

    X
  • Published: November 21, 2013
  • DOI: 10.1371/journal.ppat.1003790

About the Authors

Victoria Carter, Ann Underhill, Frederic Tripet, Paul Eggleston, Hilary Hurd
Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Keele, Staffordshire, United Kingdom
Ibrahima Baber, Lakamy Sylla, Mamadou B. Coulibaly, Sekou F. Traore
Malaria Research and Training Centre (MRTC), Université des Sciences, des Techniques et des Technologies de Bamako, Bamako, Mali
Mounirou Baby
Centre National de Transfusion Sanguine, Bamako, Mali
Isabelle Larget-Thiery, Agnès Zettor, Catherine Bourgouin
Institut Pasteur, Centre for Production and Infection of Anopheles (CEPIA), Parasitology and Mycology Department, Paris, France
Ülo Langel
Department of Neurochemistry Svante Arrhenius v. 21A, Stockholm University, Stockholm, Sweden
Ingrid Faye
Department of Molecular Bioscience, the Wenner-Gren Institute, Svante Arrhenius v. 20C, Stockholm University, Stockholm, Sweden
Laszlo Otvos
Temple University Department of Biology, Philadelphia, Pennsylvania, United States of America
John D. Wade
Howard Florey Research Laboratories, Florey Institute for Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia

Corresponding Author

Email: p.eggleston@keele.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HH VC MBC SFT FT PE. Performed the experiments: VC AU HH ILT CB AZ IB LS. Analyzed the data: VC. Contributed reagents/materials/analysis tools: CB UL IF LO JDW MB. Wrote the paper: VC HH. Reviewed/commented on the manuscript: VC HH PE LO CB.