Advertisement
Research Article

Loss of Circulating CD4 T Cells with B Cell Helper Function during Chronic HIV Infection

  • Kristin L. Boswell,

    Affiliation: Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Robert Paris,

    Affiliations: Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America, United States Military HIV Research Program, Rockville, Maryland, United States of America

    X
  • Eli Boritz,

    Affiliation: Human Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • David Ambrozak,

    Affiliation: Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Takuya Yamamoto,

    Affiliation: Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Sam Darko,

    Affiliation: Human Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Kaska Wloka,

    Affiliation: Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Adam Wheatley,

    Affiliation: Immunology Core Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Sandeep Narpala,

    Affiliation: Immunology Core Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Adrian McDermott,

    Affiliation: Immunology Core Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Mario Roederer,

    Affiliation: ImmunoTechnology Section, Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Richard Haubrich,

    Affiliation: Division of Infectious Diseases, Antiviral Research Center, University of California San Diego, San Diego, California, United States of America

    X
  • Mark Connors,

    Affiliation: HIV-Specific Immunity Section, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Julie Ake,

    Affiliation: United States Military HIV Research Program, Rockville, Maryland, United States of America

    X
  • Daniel C. Douek,

    Affiliation: Human Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Jerome Kim,

    Affiliation: United States Military HIV Research Program, Rockville, Maryland, United States of America

    X
  • Constantinos Petrovas mail,

    petrovasc@mail.nih.gov

    Affiliation: Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Richard A. Koup

    Affiliation: Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Published: January 30, 2014
  • DOI: 10.1371/journal.ppat.1003853

About the Authors

Kristin L. Boswell, Robert Paris, David Ambrozak, Takuya Yamamoto, Kaska Wloka, Constantinos Petrovas, Richard A. Koup
Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America
Robert Paris, Julie Ake, Jerome Kim
United States Military HIV Research Program, Rockville, Maryland, United States of America
Eli Boritz, Sam Darko, Daniel C. Douek
Human Immunology Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America
Adam Wheatley, Sandeep Narpala, Adrian McDermott
Immunology Core Section, Vaccine Research Center, NIAID, NIH, Bethesda, Maryland, United States of America
Mario Roederer
ImmunoTechnology Section, Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, United States of America
Richard Haubrich
Division of Infectious Diseases, Antiviral Research Center, University of California San Diego, San Diego, California, United States of America
Mark Connors
HIV-Specific Immunity Section, Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, United States of America

Corresponding Author

Email: petrovasc@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KLB RP TY CP RAK. Performed the experiments: KLB RP EB DA TY KW AW SN CP. Analyzed the data: KLB RP EB TY SD KW AW SN CP. Contributed reagents/materials/analysis tools: AM MR RH MC JA DCD JK. Wrote the paper: KLB RP TY CP RAK.