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Research Article

Group B Streptococcal Infection of the Choriodecidua Induces Dysfunction of the Cytokeratin Network in Amniotic Epithelium: A Pathway to Membrane Weakening

  • Jeroen P. Vanderhoeven,

    Affiliation: Department of Obstetrics & Gynecology, University of Washington, Seattle, Washington, United States of America

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  • Craig J. Bierle,

    Affiliation: Center for Childhood Infections and Prematurity Research, Seattle Children's Research Institute, Seattle, Washington, United States of America

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  • Raj P. Kapur,

    Affiliation: Departments of Pathology, Seattle Children's and University of Washington, Seattle, Washington, United States of America

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  • Ryan M. McAdams,

    Affiliation: Department of Pediatrics, University of Washington, Seattle, Washington, United States of America

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  • Richard P. Beyer,

    Affiliation: Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America

    X
  • Theo K. Bammler,

    Affiliation: Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America

    X
  • Federico M. Farin,

    Affiliation: Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America

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  • Aasthaa Bansal,

    Affiliation: Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

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  • Min Spencer,

    Affiliation: Center on Human Development and Disability, University of Washington, Seattle, Washington, United States of America

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  • Mei Deng,

    Affiliation: Center on Human Development and Disability, University of Washington, Seattle, Washington, United States of America

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  • Michael G. Gravett,

    Affiliations: Department of Obstetrics & Gynecology, University of Washington, Seattle, Washington, United States of America, Global Alliance to Prevent Prematurity & Stillbirth, Seattle, Washington, United States of America

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  • Craig E. Rubens,

    Affiliations: Center for Childhood Infections and Prematurity Research, Seattle Children's Research Institute, Seattle, Washington, United States of America, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America, Global Alliance to Prevent Prematurity & Stillbirth, Seattle, Washington, United States of America

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  • Lakshmi Rajagopal mail,

    lakshmi.rajagopal@seattlechildrens.org (LR); adamsk@u.washington.edu (KMAW)

    Affiliations: Center for Childhood Infections and Prematurity Research, Seattle Children's Research Institute, Seattle, Washington, United States of America, Department of Pediatrics, University of Washington, Seattle, Washington, United States of America

    X
  • Kristina M. Adams Waldorf mail

    lakshmi.rajagopal@seattlechildrens.org (LR); adamsk@u.washington.edu (KMAW)

    Affiliations: Department of Obstetrics & Gynecology, University of Washington, Seattle, Washington, United States of America, Center on Human Development and Disability, University of Washington, Seattle, Washington, United States of America

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  • Published: March 06, 2014
  • DOI: 10.1371/journal.ppat.1003920

About the Authors

Jeroen P. Vanderhoeven, Michael G. Gravett, Kristina M. Adams Waldorf
Department of Obstetrics & Gynecology, University of Washington, Seattle, Washington, United States of America
Craig J. Bierle, Craig E. Rubens, Lakshmi Rajagopal
Center for Childhood Infections and Prematurity Research, Seattle Children's Research Institute, Seattle, Washington, United States of America
Raj P. Kapur
Departments of Pathology, Seattle Children's and University of Washington, Seattle, Washington, United States of America
Ryan M. McAdams, Craig E. Rubens, Lakshmi Rajagopal
Department of Pediatrics, University of Washington, Seattle, Washington, United States of America
Richard P. Beyer, Theo K. Bammler, Federico M. Farin
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, United States of America
Aasthaa Bansal
Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
Min Spencer, Mei Deng, Kristina M. Adams Waldorf
Center on Human Development and Disability, University of Washington, Seattle, Washington, United States of America
Michael G. Gravett, Craig E. Rubens
Global Alliance to Prevent Prematurity & Stillbirth, Seattle, Washington, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JPV RMM KMAW LR RPK MGG CER CJB. Performed the experiments: KMAW RPK JPV MS MD. Analyzed the data: JPV RMM RPB TKB FMF MS RPK AB MS KMAW CJB. Contributed reagents/materials/analysis tools: RPK TKB RPB FMF. Wrote the paper: JPV RMM TKB LR RPK KMAW CJB.