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Research Article

A Polysaccharide Virulence Factor from Aspergillus fumigatus Elicits Anti-inflammatory Effects through Induction of Interleukin-1 Receptor Antagonist

  • Mark S. Gresnigt,

    Affiliation: Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Silvia Bozza,

    Affiliation: Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

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  • Katharina L. Becker,

    Affiliation: Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Leo A. B. Joosten,

    Affiliation: Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Shahla Abdollahi-Roodsaz,

    Affiliation: Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Wim B. van der Berg,

    Affiliation: Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Charles A. Dinarello,

    Affiliations: Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands, Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America

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  • Mihai G. Netea,

    Affiliation: Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Thierry Fontaine,

    Affiliation: Unité des Aspergillus, Institut Pasteur, Paris, France

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  • Antonella De Luca,

    Affiliation: Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

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  • Silvia Moretti,

    Affiliation: Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

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  • Luigina Romani mail,

    luigina.romani@unipg.it (LR); jean-paul.latge@pasteur.fr (JPL); frank.vandeveerdonk@aig.umcn.nl (FLvdV)

    Affiliation: Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy

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  • Jean-Paul Latge mail,

    luigina.romani@unipg.it (LR); jean-paul.latge@pasteur.fr (JPL); frank.vandeveerdonk@aig.umcn.nl (FLvdV)

    Affiliation: Unité des Aspergillus, Institut Pasteur, Paris, France

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  • Frank L. van de Veerdonk mail

    luigina.romani@unipg.it (LR); jean-paul.latge@pasteur.fr (JPL); frank.vandeveerdonk@aig.umcn.nl (FLvdV)

    Affiliation: Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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  • Published: March 06, 2014
  • DOI: 10.1371/journal.ppat.1003936

About the Authors

Mark S. Gresnigt, Katharina L. Becker, Leo A. B. Joosten, Charles A. Dinarello, Mihai G. Netea, Frank L. van de Veerdonk
Department of Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
Silvia Bozza, Antonella De Luca, Silvia Moretti, Luigina Romani
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
Shahla Abdollahi-Roodsaz, Wim B. van der Berg
Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands
Charles A. Dinarello
Department of Medicine, University of Colorado Denver, Aurora, Colorado, United States of America
Thierry Fontaine, Jean-Paul Latge
Unité des Aspergillus, Institut Pasteur, Paris, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LABJ CAD MGN JPL LR FLvdV. Performed the experiments: MSG SB TF ADL SM KLB. Analyzed the data: MSG CAD MGN LR JPL FLvdV. Contributed reagents/materials/analysis tools: LABJ SAR WBvdB CAD TF. Wrote the paper: MSG MGN LR JPL FLvdV.