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Research Article

Infection of Adult Thymus with Murine Retrovirus Induces Virus-Specific Central Tolerance That Prevents Functional Memory CD8+ T Cell Differentiation

  • Shiki Takamura mail,

    takamura@med.kindai.ac.jp (ST); masaaki@med.kindai.ac.jp (MM)

    Affiliation: Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan

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  • Eiji Kajiwara,

    Affiliation: Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan

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  • Sachiyo Tsuji-Kawahara,

    Affiliation: Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan

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  • Tomoko Masumoto,

    Affiliation: Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan

    X
  • Makoto Fujisawa,

    Affiliation: Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan

    X
  • Maiko Kato,

    Affiliation: Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan

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  • Tomomi Chikaishi,

    Affiliation: Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan

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  • Yuri Kawasaki,

    Affiliation: Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan

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  • Saori Kinoshita,

    Affiliation: Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan

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  • Manami Itoi,

    Affiliation: Department of Immunology and Microbiology, Meiji University of Integrative Medicine, Kyoto, Japan

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  • Nobuo Sakaguchi,

    Affiliation: Department of Immunology, Kumamoto University School of Medicine, Kumamoto, Japan

    X
  • Masaaki Miyazawa mail

    takamura@med.kindai.ac.jp (ST); masaaki@med.kindai.ac.jp (MM)

    Affiliation: Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan

    X
  • Published: March 20, 2014
  • DOI: 10.1371/journal.ppat.1003937

About the Authors

Shiki Takamura, Eiji Kajiwara, Sachiyo Tsuji-Kawahara, Tomoko Masumoto, Makoto Fujisawa, Maiko Kato, Tomomi Chikaishi, Yuri Kawasaki, Saori Kinoshita, Masaaki Miyazawa
Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan
Manami Itoi
Department of Immunology and Microbiology, Meiji University of Integrative Medicine, Kyoto, Japan
Nobuo Sakaguchi
Department of Immunology, Kumamoto University School of Medicine, Kumamoto, Japan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ST. Performed the experiments: ST EK STK TM MF MK TC YK SK. Analyzed the data: ST MM. Contributed reagents/materials/analysis tools: ST EK MI NS MM. Wrote the paper: ST MM.