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Research Article

Target Cell Availability, Rather than Breast Milk Factors, Dictates Mother-to-Infant Transmission of SIV in Sooty Mangabeys and Rhesus Macaques

  • Ann Chahroudi mail,

    achahro@emory.edu

    Affiliations: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America, Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • Emily Cartwright,

    Affiliation: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • S. Thera Lee,

    Affiliations: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America, Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • Maud Mavigner,

    Affiliations: Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America, Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • Diane G. Carnathan,

    Affiliation: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • Benton Lawson,

    Affiliation: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • Paul M. Carnathan,

    Affiliation: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • Tayebeh Hashempoor,

    Affiliation: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • Megan K. Murphy,

    Affiliation: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • Tracy Meeker,

    Affiliation: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • Stephanie Ehnert,

    Affiliation: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • Christopher Souder,

    Affiliation: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • James G. Else,

    Affiliations: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America, Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Joyce Cohen,

    Affiliation: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • Ronald G. Collman,

    Affiliation: University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Thomas H. Vanderford,

    Affiliation: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America

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  • Sallie R. Permar,

    Affiliation: Duke Human Vaccine Institute, Durham, North Carolina, United States of America

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  • Cynthia A. Derdeyn,

    Affiliations: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America, Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Francois Villinger,

    Affiliations: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America, Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Guido Silvestri

    Affiliations: Yerkes National Primate Research Center, Atlanta, Georgia, United States of America, Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Published: March 06, 2014
  • DOI: 10.1371/journal.ppat.1003958

About the Authors

Ann Chahroudi, S. Thera Lee, Maud Mavigner
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
Ann Chahroudi, Emily Cartwright, S. Thera Lee, Maud Mavigner, Diane G. Carnathan, Benton Lawson, Paul M. Carnathan, Tayebeh Hashempoor, Megan K. Murphy, Tracy Meeker, Stephanie Ehnert, Christopher Souder, James G. Else, Joyce Cohen, Thomas H. Vanderford, Cynthia A. Derdeyn, Francois Villinger, Guido Silvestri
Yerkes National Primate Research Center, Atlanta, Georgia, United States of America
James G. Else, Cynthia A. Derdeyn, Francois Villinger, Guido Silvestri
Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America
Ronald G. Collman
University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
Sallie R. Permar
Duke Human Vaccine Institute, Durham, North Carolina, United States of America

Corresponding Author

Email: achahro@emory.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AC MM TM SE CS JGE JC THV CAD FV GS. Performed the experiments: AC EC STL MM DGC BL PMC TH MKM. Analyzed the data: AC MM MKM THV. Contributed reagents/materials/analysis tools: RGC. Wrote the paper: AC GS. Pioneered a protocol: SRP.