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Research Article

Influenza A Virus Assembly Intermediates Fuse in the Cytoplasm

  • Seema S. Lakdawala mail,

    Seema.Lakdawala@nih.gov (SSL); Hari.Shroff@nih.gov (HS)

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Yicong Wu,

    Affiliation: Section on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Peter Wawrzusin,

    Affiliation: Section on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Juraj Kabat,

    Affiliation: Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Andrew J. Broadbent,

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Elaine W. Lamirande,

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Ervin Fodor,

    Affiliation: Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom

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  • Nihal Altan-Bonnet,

    Affiliation: Laboratory of Host-Pathogen Dynamics, Cell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Hari Shroff mail,

    Seema.Lakdawala@nih.gov (SSL); Hari.Shroff@nih.gov (HS)

    Affiliation: Section on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Kanta Subbarao

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Published: March 06, 2014
  • DOI: 10.1371/journal.ppat.1003971

About the Authors

Seema S. Lakdawala, Andrew J. Broadbent, Elaine W. Lamirande, Kanta Subbarao
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Yicong Wu, Peter Wawrzusin, Hari Shroff
Section on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, United States of America
Juraj Kabat
Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Ervin Fodor
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
Nihal Altan-Bonnet
Laboratory of Host-Pathogen Dynamics, Cell Biology and Physiology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SSL YW HS KS. Performed the experiments: SSL YW AJB EWL. Analyzed the data: SSL YW PW JK HS KS. Contributed reagents/materials/analysis tools: JK EF NAB. Wrote the paper: SSL HS KS.