Advertisement
Research Article

Chronic Exposure to Type-I IFN under Lymphopenic Conditions Alters CD4 T Cell Homeostasis

  • Cecile Le Saout,

    Affiliation: CMRS/Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Rebecca B. Hasley,

    Affiliation: CMRS/Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Hiromi Imamichi,

    Affiliation: CMRS/Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Lueng Tcheung,

    Affiliation: CMRS/Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Zonghui Hu,

    Affiliation: Biostatistics Research Branch, DCR, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Megan A. Luckey,

    Affiliation: Experimental Immunology Branch, CCR, NCI, NIH, Bethesda, Maryland, United States of America

    X
  • Jung-Hyun Park,

    Affiliation: Experimental Immunology Branch, CCR, NCI, NIH, Bethesda, Maryland, United States of America

    X
  • Scott K. Durum,

    Affiliation: Laboratory of Immunoregulation, CCR, NCI, NIH, Frederick, Maryland, United States of America

    X
  • Mindy Smith,

    Affiliation: CMRS/Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Adam W. Rupert,

    Affiliation: AIDS Monitoring Labs. Leidos Biomedical Research, Inc, Frederick, Maryland, United States of America

    X
  • Michael C. Sneller,

    Affiliation: CMRS/Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • H. Clifford Lane,

    Affiliation: CMRS/Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Marta Catalfamo mail

    catalfam@mail.nih.gov

    Affiliation: CMRS/Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, United States of America

    X
  • Published: March 06, 2014
  • DOI: 10.1371/journal.ppat.1003976

About the Authors

Cecile Le Saout, Rebecca B. Hasley, Hiromi Imamichi, Lueng Tcheung, Mindy Smith, Michael C. Sneller, H. Clifford Lane, Marta Catalfamo
CMRS/Laboratory of Immunoregulation, NIAID, NIH, Bethesda, Maryland, United States of America
Zonghui Hu
Biostatistics Research Branch, DCR, NIAID, NIH, Bethesda, Maryland, United States of America
Megan A. Luckey, Jung-Hyun Park
Experimental Immunology Branch, CCR, NCI, NIH, Bethesda, Maryland, United States of America
Scott K. Durum
Laboratory of Immunoregulation, CCR, NCI, NIH, Frederick, Maryland, United States of America
Adam W. Rupert
AIDS Monitoring Labs. Leidos Biomedical Research, Inc, Frederick, Maryland, United States of America

Corresponding Author

Email: catalfam@mail.nih.gov

Competing Interests

AWR is affiliated with AIDS Monitoring Labs, Leidos Biomedical Research, Inc. This does not alter our adherence to all PLOS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CLS MC. Performed the experiments: CLS RBH LT HI ZH. Analyzed the data: CLS RBH LT HI ZH. Contributed reagents/materials/analysis tools: MAL MS JHP SKD MCS AWR. Wrote the paper: CLS HCL MC.