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Research Article

A Non-Coding RNA Promotes Bacterial Persistence and Decreases Virulence by Regulating a Regulator in Staphylococcus aureus

  • Cédric Romilly equal contributor,

    equal contributor Contributed equally to this work with: Cédric Romilly, Claire Lays

    Affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France

    Current address: Department of Cell and Molecular Biology, microbiology program, Biomedical Center, Uppsala University, Uppsala, Sweden.

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  • Claire Lays equal contributor,

    equal contributor Contributed equally to this work with: Cédric Romilly, Claire Lays

    Affiliations: CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France, Inserm U1111, Lyon, France, Ecole Normale Supérieure de Lyon, Lyon, France, Université Lyon 1, Lyon, France, CNRS, UMR5308, Lyon, France

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  • Arnaud Tomasini,

    Affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France

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  • Isabelle Caldelari,

    Affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France

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  • Yvonne Benito,

    Affiliations: CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France, Inserm U1111, Lyon, France, Ecole Normale Supérieure de Lyon, Lyon, France, Université Lyon 1, Lyon, France, CNRS, UMR5308, Lyon, France, Hospices Civils de Lyon, Lyon, France

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  • Philippe Hammann,

    Affiliation: Plateforme Protéomique IBMC, Strasbourg, France

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  • Thomas Geissmann,

    Affiliations: CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France, Inserm U1111, Lyon, France, Ecole Normale Supérieure de Lyon, Lyon, France, Université Lyon 1, Lyon, France, CNRS, UMR5308, Lyon, France

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  • Sandrine Boisset,

    Affiliations: CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France, Inserm U1111, Lyon, France, Ecole Normale Supérieure de Lyon, Lyon, France, Université Lyon 1, Lyon, France, CNRS, UMR5308, Lyon, France, Hospices Civils de Lyon, Lyon, France

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  • Pascale Romby mail,

    p.romby@ibmc-cnrs.unistra.fr (PR); francois.vandenesch@univ-lyon1.fr (FV)

    Affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France

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  • François Vandenesch mail

    p.romby@ibmc-cnrs.unistra.fr (PR); francois.vandenesch@univ-lyon1.fr (FV)

    Affiliations: CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France, Inserm U1111, Lyon, France, Ecole Normale Supérieure de Lyon, Lyon, France, Université Lyon 1, Lyon, France, CNRS, UMR5308, Lyon, France, Hospices Civils de Lyon, Lyon, France

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  • Published: March 20, 2014
  • DOI: 10.1371/journal.ppat.1003979

About the Authors

Cédric Romilly, Arnaud Tomasini, Isabelle Caldelari, Pascale Romby
Architecture et Réactivité de l'ARN, Université de Strasbourg, CNRS, IBMC, Strasbourg, France
Claire Lays, Yvonne Benito, Thomas Geissmann, Sandrine Boisset, François Vandenesch
CIRI, International Center for Infectiology Research, Université de Lyon, Lyon, France
Claire Lays, Yvonne Benito, Thomas Geissmann, Sandrine Boisset, François Vandenesch
Inserm U1111, Lyon, France
Claire Lays, Yvonne Benito, Thomas Geissmann, Sandrine Boisset, François Vandenesch
Ecole Normale Supérieure de Lyon, Lyon, France
Claire Lays, Yvonne Benito, Thomas Geissmann, Sandrine Boisset, François Vandenesch
Université Lyon 1, Lyon, France
Claire Lays, Yvonne Benito, Thomas Geissmann, Sandrine Boisset, François Vandenesch
CNRS, UMR5308, Lyon, France
Yvonne Benito, Sandrine Boisset, François Vandenesch
Hospices Civils de Lyon, Lyon, France
Philippe Hammann
Plateforme Protéomique IBMC, Strasbourg, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CR CL AT IC YB PH TG SB PR FV. Performed the experiments: CR CL AT YB TG SB PH. Analyzed the data: CR CL AT IC TG SB PH PR FV. Wrote the paper: CR CL TG SB PR FV.