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Research Article

PPARγ Agonists Improve Survival and Neurocognitive Outcomes in Experimental Cerebral Malaria and Induce Neuroprotective Pathways in Human Malaria

  • Lena Serghides mail,

    lena.serghides@utoronto.ca

    Affiliations: Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada, SA Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network, Toronto, Ontario, Canada, Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada

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  • Chloe R. McDonald equal contributor,

    equal contributor Contributed equally to this work with: Chloe R. McDonald, Ziyue Lu

    Affiliations: SA Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network, Toronto, Ontario, Canada, Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Ziyue Lu equal contributor,

    equal contributor Contributed equally to this work with: Chloe R. McDonald, Ziyue Lu

    Affiliations: SA Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network, Toronto, Ontario, Canada, Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Miriam Friedel,

    Affiliation: Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada

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  • Cheryl Cui,

    Affiliation: Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Keith T. Ho,

    Affiliation: Department of Physiology, University of Toronto, Toronto, Ontario, Canada

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  • Howard T. J. Mount,

    Affiliations: Department of Physiology, University of Toronto, Toronto, Ontario, Canada, Department of Psychiatry, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • John G. Sled,

    Affiliations: Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

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  • Kevin C. Kain

    Affiliations: Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada, SA Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network, Toronto, Ontario, Canada, Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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  • Published: March 06, 2014
  • DOI: 10.1371/journal.ppat.1003980

About the Authors

Lena Serghides, Kevin C. Kain
Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
Lena Serghides, Chloe R. McDonald, Ziyue Lu, Kevin C. Kain
SA Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network, Toronto, Ontario, Canada
Lena Serghides
Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada
Chloe R. McDonald, Ziyue Lu, Cheryl Cui, Kevin C. Kain
Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Miriam Friedel, John G. Sled
Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada
Keith T. Ho, Howard T. J. Mount
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Howard T. J. Mount
Department of Psychiatry, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
John G. Sled
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

Corresponding Author

Email: lena.serghides@utoronto.ca

Competing Interests

I have read the journal's policy and have the following conflicts: The University Health Network holds intellectual property pertaining to the use of PPARγ agonists for the treatment of severe malaria. The authors have no other financial interests related to this work. This does not alter our adherence to all PLOS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LS CRM KCK. Performed the experiments: LS CRM ZL CC MF. Analyzed the data: LS CRM ZL MF JGS KCK. Contributed reagents/materials/analysis tools: JGS KTH HTJM. Wrote the paper: LS KCK.