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Research Article

Post-Translational Regulation via Clp Protease Is Critical for Survival of Mycobacterium tuberculosis

  • Ravikiran M. Raju,

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Mark P. Jedrychowski,

    Affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jun-Rong Wei,

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Jessica T. Pinkham,

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Annie S. Park,

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Kathryn O'Brien,

    Affiliation: Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

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  • German Rehren,

    Affiliation: Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

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  • Dirk Schnappinger,

    Affiliation: Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

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  • Steven P. Gygi,

    Affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Eric J. Rubin mail

    erubin@hsph.harvard.edu

    Affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America

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  • Published: March 06, 2014
  • DOI: 10.1371/journal.ppat.1003994

About the Authors

Ravikiran M. Raju, Jun-Rong Wei, Jessica T. Pinkham, Annie S. Park, Eric J. Rubin
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
Mark P. Jedrychowski, Steven P. Gygi
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America
Kathryn O'Brien, German Rehren, Dirk Schnappinger
Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

Corresponding Author

Email: erubin@hsph.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RMR MPJ SPG EJR. Performed the experiments: RMR MPJ JRW JTP ASP. Analyzed the data: RMR MPJ. Contributed reagents/materials/analysis tools: KO GR DS. Wrote the paper: RMR EJR.